지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 123 - 132 (10page)
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Obesity is consistently increasing in prevalence and can trigger insulin resistance and type 2 diabetes. Many lines of evidence have shown that macrophages play a major role in inflammation associated with obesity. This study was conducted to determine metformin, a widely prescribed drug for type 2 diabetes, would regulate inflammation through downregulation of scavenger receptors in macrophages from obesity-induced type 2 diabetes. RAW 264.7 cells and peritoneal macrophages were stimulated with LPS to induce inflammation, and C57BL/6N mice were fed a high-fat diet to generate obesity-induced type 2 diabetes mice. Metformin reduced the production of NO, PGE2 and pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) through down-regulation of NF-κB translocation in macrophages in a dose-dependent manner. On the other hand, the protein expressions of anti-inflammatory cytokines, IL-4 and IL-10, were enhanced or maintained by metformin. Also, metformin suppressed secretion of TNF-αand reduced the protein and mRNA
expression of TNF-α in obese mice as well as in macrophages. The expression of scavenger receptors, CD36 and SR-A, were attenuated by metformin in macrophages and obese mice. These results suggest that metformin may attenuate inflammatory responses by suppressing the production of TNF-α and the expressions of scavenger receptors.
expression of TNF-α in obese mice as well as in macrophages. The expression of scavenger receptors, CD36 and SR-A, were attenuated by metformin in macrophages and obese mice. These results suggest that metformin may attenuate inflammatory responses by suppressing the production of TNF-α and the expressions of scavenger receptors.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (57)
참고문헌 신청
1. [학술지(정기간행물)] - Flegal, K. M. / 2010 / Prevalence and trends in obesity among US adults, 1999-2008 / JAMA 303 : 235 ~ 241
2. [학술지(정기간행물)] - 배남규 / 2009 / 한국인의 10년간 비만수준의 변화 양상: 1997~2007 / 대한비만학회지 18 (1) : 24 ~ 30
3. [학술지(정기간행물)] - Mokdad, A. H. / 2003 / Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 / JAMA 289 : 76 ~ 79
4. [학술지(정기간행물)] - Grundy, S. M. / 2004 / Obesity, metabolic syndrome, and cardiovascular disease / J. Clin. Endocrinol. Metab 89 : 2595 ~ 2600
5. [학술지(정기간행물)] - Shaw, J. E. / 2010 / Global estimates of the prevalence of diabetes for 2010 and 2030 / Diabetes. Res. Clin. Pract 87 : 4 ~ 14
2. [학술지(정기간행물)] - 배남규 / 2009 / 한국인의 10년간 비만수준의 변화 양상: 1997~2007 / 대한비만학회지 18 (1) : 24 ~ 30
3. [학술지(정기간행물)] - Mokdad, A. H. / 2003 / Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 / JAMA 289 : 76 ~ 79
4. [학술지(정기간행물)] - Grundy, S. M. / 2004 / Obesity, metabolic syndrome, and cardiovascular disease / J. Clin. Endocrinol. Metab 89 : 2595 ~ 2600
5. [학술지(정기간행물)] - Shaw, J. E. / 2010 / Global estimates of the prevalence of diabetes for 2010 and 2030 / Diabetes. Res. Clin. Pract 87 : 4 ~ 14
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UCI(KEPA) : I410-ECN-0101-2016-511-001746073