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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 91 - 99 (9page)
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초록· 키워드
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Herpes simplex virus (HSV) is a common causative agent of genital ulceration and can lead to subsequent neurological disease in some cases. Here, using a genital infection model, we tested the efficacy of vinegar-processed flos of Daphne genkwa (vp-genkwa) to modulate vaginal inflammation caused by HSV-1 infection. Our data revealed that treatment with optimal doses of vp-genkwa after, but not before, HSV-1 infection provided enhanced resistance against HSV-1 infection, as corroborated by reduced mortality and clinical signs. Consistent with these results, treatment with vp-genkwa after HSV-1 infection reduced viral replication in the vaginal tract. Furthermore, somewhat intriguingly, treatment of vp-genkwa after HSV-1 infection increased the frequency and absolute number of CD3<SUP>?</SUP>NK1.1<SUP>＋</SUP>NKp46<SUP>＋</SUP> natural killer (NK) cells producing interferon (IFN)-γ and granyzme B, which indicates that vp-genkwa treatment induces the activation of NK cells. Supportively, secreted IFN-γ was detected at an increased level in vaginal lavages of mice treated with vp-genkwa after HSV-1 infection. These results indicate that enhanced resistance to HSV-1 infection by treatment with vp-genkwa is associated with NK cell activation. Therefore, our data provide a valuable insight into the use of vp-genkwa to control clinical severity in HSV infection through NK cell activation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Shahin, V. / 2006 / The genome of HSV-1 translocates through the nuclear pore as a condensed rod-like structure / J. Cell Sci 119 : 23 ~ 30
2. [학술지(정기간행물)] - Daniels, D. / 2008 / Mixed HSV-1 HSV-2infection in a patient attending a GUM clinic / Br. J. Biomed. Sci 65 : 203 ~ 204
3. [학술지(정기간행물)] - Pereira, V. S. / 2012 / Herpes simplex virus type 1 is the main cause of genital herpes in women of Natal, Brazil / Eur. J. Obstet. Gynecol. Reprod. Biol 161 : 190 ~ 193
4. [학술지(정기간행물)] - Lee, A. J. / 2012 / Herpes simplex virus-2in the genital mucosa: insights into the mucosal host response vaccine development / Curr. Opin. Infect. Dis 25 : 92 ~ 99
5. [학술지(정기간행물)] - Chentoufi, A.A. / 2012 / Mucosal herpes immunity immunopathology to ocular genital herpes simplex virus infections / Clin. Dev. Immunol : 149135 ~
2. [학술지(정기간행물)] - Daniels, D. / 2008 / Mixed HSV-1 HSV-2infection in a patient attending a GUM clinic / Br. J. Biomed. Sci 65 : 203 ~ 204
3. [학술지(정기간행물)] - Pereira, V. S. / 2012 / Herpes simplex virus type 1 is the main cause of genital herpes in women of Natal, Brazil / Eur. J. Obstet. Gynecol. Reprod. Biol 161 : 190 ~ 193
4. [학술지(정기간행물)] - Lee, A. J. / 2012 / Herpes simplex virus-2in the genital mucosa: insights into the mucosal host response vaccine development / Curr. Opin. Infect. Dis 25 : 92 ~ 99
5. [학술지(정기간행물)] - Chentoufi, A.A. / 2012 / Mucosal herpes immunity immunopathology to ocular genital herpes simplex virus infections / Clin. Dev. Immunol : 149135 ~
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UCI(KEPA) : I410-ECN-0101-2016-511-001746331