A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly

Yoshiko Fukuyama; Yorihiko Ikeda; Junichiro Ohori; Gen Sugita; Kazuyoshi Aso; Keiko Fujihashi; David E. Briles; Jerry R. McGhee; Kohtaro Fujihashi

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자료유형: 학술저널

저자정보: Yoshiko Fukuyama (The University of Tokyo) Yorihiko Ikeda (The University of Alabama at Birmingham) Junichiro Ohori (The University of Alabama at Birmingham) Gen Sugita (The University of Alabama at Birmingham) Kazuyoshi Aso (The University of Alabama at Birmingham) Keiko Fujihashi (The University of Alabama at Birmingham) David E. Briles (The University of Alabama at Birmingham) Jerry R. McGhee (The University of Alabama at Birmingham) Kohtaro Fujihashi (The University of Alabama at Birmingham)

저널정보: 대한면역학회 Immune Network Immune Network Vol.15 No.1

발행연도: 2015.2

수록면: 9 - 15 (7page)

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Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosal IgA antibody responses in older individuals. A combind nasal adjuvant consisting of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligonucleotide (CpG ODN) successfully enhanced S. pneumoniae-specific mucosal immunity in aged mice. In particular, a pneumococcal surface protein A-based nasal vaccine given with pFL and CpG ODN induced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNA adjuvant offers an attractive potential for protection against the pneumococcus in the elderly.

#Mucosa #Vaccination #Aging #Bacterial infection

참고문헌 (66)

참고문헌 신청

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2. [단행본] - Kiyono, H. / 2008 / Fundamental Immunology / Lippincott Williams & Wilkins : 983 ~ 1030

3. [학술지(정기간행물)] - Campbell, D. J. / 2002 / Rapid acquisition of tissue-specific homing phenotypes by CD4＋ T cells activated in cutaneous or mucosal lymphoid tissues / J. Exp. Med 195 : 135 ~ 141

4. [학술지(정기간행물)] - Campbell, J. J. / 2001 / Expression of chemokine receptors by lung T cells from normal and asthmatic subjects / J. Immunol 166 : 2842 ~ 2848

5. [학술지(정기간행물)] - Csencsits, K. L. / 2001 / Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: α(E) versus L-selectin / J. Immunol 167 : 2441 ~ 2445

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Yoshiko Fukuyama

소속기관 The University of Tokyo

주요연구분야 의약학 > 기초의학 > 면역학

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Yorihiko Ikeda