지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.2
- 수록면
- 30 - 33 (4page)
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초록· 키워드
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Previously we showed that biodegradable nanoparticles containing poly-IC or CpG oligodeoxynucleotide (ODN) together with ovalbumin (OVA) were efficient at inducing MHC-restricted presentation of OVA peptides in dendritic cells. The CTL-inducing activities of the nanoparticles were examined in the present study. Nanoparticles containing poly-IC or CpG ODN together with OVA were prepared using biodegradable polymer poly(D,L-lactic acid-co-glycolic acid), and then were opsonized with mouse IgG. The nanoparticles were injected into the tail vein of mice, and 7 days later the OVA-specific CTL activities were measured using an in vivo CTL assay. Immunization of mice with the nanoparticles containing poly-IC or CpG ODN together with OVA elicited potent OVA-specific CTL activity compared to those containing OVA only. In accordance with these results, nanoparticles containing poly-IC or CpG ODN together with OVA exerted potent antitumor activity in mice that were subcutaneously implanted with EG7.OVA tumor cells. These results show that encapsulation of poly-IC or CpG ODN together with antigen in biodegradable nanoparticles is an effective approach for the induction of potent antigen-specific CTL responses in vivo.
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참고문헌 (19)
참고문헌 신청
Van Der Bruggen. P / 2002 / Tumor-specific shared antigenic peptides recognized by human T cells / Immunol. Rev 188:51~64
Huang, A. Y. / 1994 / Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens / Science 264:961~965
Harding, C. V. / 1995 / Phagocytic processing of antigens for presentation by MHC molecules / Trends Cell Biol 5:105~109
Sigal, L. J. / 1999 / Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen / Nature 398:77~80
Heath, W. R / 2001 / Cross-presentation, dendritic cells, tolerance and immunity / Annu. Rev. Immunol 19:47~64
Huang, A. Y. / 1994 / Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens / Science 264:961~965
Harding, C. V. / 1995 / Phagocytic processing of antigens for presentation by MHC molecules / Trends Cell Biol 5:105~109
Sigal, L. J. / 1999 / Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen / Nature 398:77~80
Heath, W. R / 2001 / Cross-presentation, dendritic cells, tolerance and immunity / Annu. Rev. Immunol 19:47~64
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UCI(KEPA) : I410-ECN-0101-2016-511-001746215