지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 102 - 106 (5page)
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초록· 키워드
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Emerging evidence suggests that gap formation and opening of the endothelial junctions during leukocyte extravasation is actively controlled to maintain the integrity of the vascular barrier. While the role for endothelial cells to this process has been well defined, it is not clear whether leukocytes are also actively contributing to endothelial barrier function. We have recently showed that extravasating leukocytes deposit microparticles on the subendothelium during the late stages of extravasation, which is LFA-1 dependent. Using multiphotonintravital microscopy (MP-IVM) of mouse cremaster muscle vessels in the current work, we show that microparticle formation and deposition maintains the integrity of the microvascular barrier during leukocyte extravasation. Inhibition of neutrophil-derived microparticle formation resulted in dramatically increased vascular leakage. These findings suggest that deposition of microparticles during neutrophil extravasation is essential for maintaining endothelial barrier function and may result in temporal difference between neutrophil extravasation and an increase in vascular leakage.
목차
INTRODUCTION
MATERIALS AND METHODS
Results and Discussion
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Phillipson, M. / 2006 / Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade / J. Exp. Med 203 : 2569 ~ 2575
2. [학술지(정기간행물)] - Shulman, Z. / 2009 / Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin / Immunity 30 : 384 ~ 396
3. [학술지(정기간행물)] - Sumagin, R. / 2010 / LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ / J. Immunol 185 : 7057 ~ 7066
4. [학술지(정기간행물)] - Auffray, C. / 2007 / Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior / Science 317 : 666 ~ 670
5. [학술지(정기간행물)] - Hyun, Y. M. / 2012 / Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels / J. Exp. Med 209 : 1349 ~ 1362
2. [학술지(정기간행물)] - Shulman, Z. / 2009 / Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin / Immunity 30 : 384 ~ 396
3. [학술지(정기간행물)] - Sumagin, R. / 2010 / LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ / J. Immunol 185 : 7057 ~ 7066
4. [학술지(정기간행물)] - Auffray, C. / 2007 / Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior / Science 317 : 666 ~ 670
5. [학술지(정기간행물)] - Hyun, Y. M. / 2012 / Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels / J. Exp. Med 209 : 1349 ~ 1362
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UCI(KEPA) : I410-ECN-0101-2016-511-001746159