지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 94 - 101 (8page)
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초록· 키워드
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Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles were investigated using 30-nm amorphous silica nanoparticles and human peripheral blood mononuclear cells (PBMCs) or purified monocytes. As a result, production of IL-1β and IL-8 were increased. In addition, the mitochondrial reactive oxygen species (ROS) was detected, which may lead to mitochondrial membrane disruption. Most importantly, inflammasome formation was observed. Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1β and IL-8.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Hirsch, L. R. / 2003 / Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance / Proc. Natl. Acad. Sci. U. S. A 100 : 13549 ~ 13554
2. [학술지(정기간행물)] - Bharali, D. J. / 2005 / Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain / Proc. Natl. Acad. Sci. U. S. A 102 : 11539 ~ 11544
3. [학술지(정기간행물)] - Roy, I. / 2005 / Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery / Proc. Natl. Acad. Sci. U. S. A 102 : 279 ~ 284
4. [학술지(정기간행물)] - Bottini, M. / 2007 / Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytes / Int. J. Nanomedicine 2 : 227 ~ 233
5. [학술지(정기간행물)] - Verraedt, E. / 2010 / Controlled release of chlorhexidine from amorphous microporous silica / J. Control. Release 142 : 47 ~ 52
2. [학술지(정기간행물)] - Bharali, D. J. / 2005 / Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain / Proc. Natl. Acad. Sci. U. S. A 102 : 11539 ~ 11544
3. [학술지(정기간행물)] - Roy, I. / 2005 / Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery / Proc. Natl. Acad. Sci. U. S. A 102 : 279 ~ 284
4. [학술지(정기간행물)] - Bottini, M. / 2007 / Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytes / Int. J. Nanomedicine 2 : 227 ~ 233
5. [학술지(정기간행물)] - Verraedt, E. / 2010 / Controlled release of chlorhexidine from amorphous microporous silica / J. Control. Release 142 : 47 ~ 52
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UCI(KEPA) : I410-ECN-0101-2016-511-001746144