지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 205 - 212 (8page)
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초록· 키워드
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Dectin-1, which specifically recognizes β-glucan of fungal cell walls, is a non-Toll-like receptor (TLR) pattern recognition receptor and a representative of C-type lectin receptors (CLRs). The importance of Dectin-1 in innate immune cells, such as dendritic cells and macrophages, has previously been well studied. However, the function of Dectin-1 in B cells is very poorly understood. To determine the role of Dectin-1 in B cell activation, we first investigated whether mouse B cells express Dectin-1 and then assessed the effect of Dectin-1 stimulation on B cell proliferation and antibody production. Mouse B cells express mRNAs encoding CLRs, including Dectin-1, and surface Dectin-1 was expressed in B cells of C57BL/6 rather than BALB/c strain. Dectin-1 agonists, heat-killed Candida albicans (HKCA) and heat-killed Saccharomyces cerevisiae (HKSC), alone induced B cell proliferation but not antibody production. Interestingly, HKSC, HKCA, and depleted zymosan (a selective Dectin-1 agonist) selectively enhanced LPS-driven IgG1 production. Taken together, these results suggest that, during fungal infection, β-glucan-stimulated Dectin-1 may cooperate with TLR4 to specifically enhance IgG1 production by mouse B cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Takeuchi, O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
2. [학술지(정기간행물)] - Michallet, M. C. / 2013 / Innate receptors for adaptive immunity / Curr. Opin. Microbiol 16 : 296 ~ 302
3. [학술지(정기간행물)] - Willment, J. A / 2008 / C-type lectin receptors in antifungal immunity / Trends Microbiol 16 : 27 ~ 32
4. [학술지(정기간행물)] - Brown, G. D. / 2011 / Innate antifungal immunity: the key role of phagocytes / Annu. Rev. Immunol 29 : 1 ~ 21
5. [학술지(정기간행물)] - Hardison, S. E. / 2012 / C-type lectin receptors orchestrate antifungal immunity / Nat. Immunol 13 : 817 ~ 822
2. [학술지(정기간행물)] - Michallet, M. C. / 2013 / Innate receptors for adaptive immunity / Curr. Opin. Microbiol 16 : 296 ~ 302
3. [학술지(정기간행물)] - Willment, J. A / 2008 / C-type lectin receptors in antifungal immunity / Trends Microbiol 16 : 27 ~ 32
4. [학술지(정기간행물)] - Brown, G. D. / 2011 / Innate antifungal immunity: the key role of phagocytes / Annu. Rev. Immunol 29 : 1 ~ 21
5. [학술지(정기간행물)] - Hardison, S. E. / 2012 / C-type lectin receptors orchestrate antifungal immunity / Nat. Immunol 13 : 817 ~ 822
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UCI(KEPA) : I410-ECN-0101-2016-511-001745778