지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 184 - 193 (10page)
이용수
초록· 키워드
오류제보하기
Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.
목차
INTRODUCTION
B7.1 AND B7.2 (CD80 AND CD86)
B7-H1 (CD274, PD-L1) AND B7-DC (CD273, PD-L2)
B7-H2 (ICOSL, CD275)
B7-H3 (CD276)
B7-H4 (B7-S1, B7x, VTCN1)
B7-H5 (PD-1H, VISTA, GI24, DIES1)
B7-H6 (NCR3LG1)
B7-H7
CONCLUSION
REFERENCES
참고문헌 (99)
참고문헌 신청
1. [학술지(정기간행물)] - Van Parijs, L. / 1998 / Homeostasis and self-tolerance in the immune system: turning lymphocytes off / Science 280 : 243 ~ 248
2. [학술지(정기간행물)] - Chen, L. / 2013 / Molecular mechanisms of T cell co-stimulation and co-inhibition / Nat. Rev. Immunol 13 : 227 ~ 242
3. [학술지(정기간행물)] - Pardoll, D. M / 2012 / The blockade of immune checkpoints in cancer immunotherapy / Nat. Rev. Cancer 12 : 252 ~ 264
4. [학술지(정기간행물)] - Saito, T. / 2010 / Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters / FEBS Lett 584 : 4865 ~ 4871
5. [학술지(정기간행물)] - Greenwald, R. J. / 2005 / The B7 family revisited / Annu. Rev. Immunol 23 : 515 ~ 548
2. [학술지(정기간행물)] - Chen, L. / 2013 / Molecular mechanisms of T cell co-stimulation and co-inhibition / Nat. Rev. Immunol 13 : 227 ~ 242
3. [학술지(정기간행물)] - Pardoll, D. M / 2012 / The blockade of immune checkpoints in cancer immunotherapy / Nat. Rev. Cancer 12 : 252 ~ 264
4. [학술지(정기간행물)] - Saito, T. / 2010 / Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters / FEBS Lett 584 : 4865 ~ 4871
5. [학술지(정기간행물)] - Greenwald, R. J. / 2005 / The B7 family revisited / Annu. Rev. Immunol 23 : 515 ~ 548
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UCI(KEPA) : I410-ECN-0101-2016-511-001745743