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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 168 - 176 (9page)
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In the last few years major progress has been made in better understanding the role of natural killer (NK) cells in hepatitis C virus (HCV) infection. This includes multiple pathways by which HCV impairs or limits NK cells activation. Based on current genetic and functional data, a picture is emerging where only a rapid and strong NK cell response early on during infection which results in strong T cell responses and possible subsequent clearance, whereas chronic HCV infection is associated with dysfunctional or biased NK cells phenotypes. The hallmark of this NK cell dysfunction is persistent activation promoting ongoing hepatitis and hepatocyte damage, while being unable to clear HCV due to impaired IFN-γ responses. Furthermore, some data suggests certain chronically activated subsets that are NKp46<SUP>high</SUP> may be particularly active against hepatic stellate cells, a key player in hepatic fibrogenesis. Finally, the role of NK cells during HCV therapy, HCV recurrence after liver transplant and hepatocellular carcinoma are discussed.
목차
INTRODUCTION
NATURAL KILLER CELLS
DIRECT INTERACTION BETWEEN NK CELLS AND HCV
ACUTE HEPATITIS C AND SPONTANEOUS RECOVERY FROM HCV INFECTION
NK CELLS IN CHRONIC HCV INFECTION
NK CELLS IN TREATMENT OF CHRONIC HCV INFECTION
NK CELLS AND HCV RECURRENCE AFTER LIVER TRANSPLANTATION
NK CELLS AND HCV-RELATED HEPATOCELLULAR CARCINOMA
CONCLUDING REMARKS
REFERENCES
참고문헌 (80)
참고문헌 신청
1. [인터넷자원] - WHO / / Fact Sheet No. 164
2. [학술지(정기간행물)] - Hoofnagle, J. H. / 2002 / Course and outcome of hepatitis C / Hepatology 36 : S21 ~ S29
3. [학술지(정기간행물)] - Burra, P. / 2009 / Hepatitis C. Semin / Liver Dis 29 : 53 ~ 65
4. [학술지(정기간행물)] - NIH office of the director / 2002 / NIH consensus statement on management of hepatitis C / NIH Consens. State. Sci. Statements 19 : 1 ~ 46
5. [학술지(정기간행물)] - Feld, J. J. / 2005 / Mechanism of action of interferon and ribavirin in treatment of hepatitis C / Nature 436 : 967 ~ 972
2. [학술지(정기간행물)] - Hoofnagle, J. H. / 2002 / Course and outcome of hepatitis C / Hepatology 36 : S21 ~ S29
3. [학술지(정기간행물)] - Burra, P. / 2009 / Hepatitis C. Semin / Liver Dis 29 : 53 ~ 65
4. [학술지(정기간행물)] - NIH office of the director / 2002 / NIH consensus statement on management of hepatitis C / NIH Consens. State. Sci. Statements 19 : 1 ~ 46
5. [학술지(정기간행물)] - Feld, J. J. / 2005 / Mechanism of action of interferon and ribavirin in treatment of hepatitis C / Nature 436 : 967 ~ 972
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UCI(KEPA) : I410-ECN-0101-2016-511-001745723