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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 275 - 282 (8page)
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초록· 키워드
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Influenza virus is one of the major sources of respiratory tract infection. Due to antigenic drift in surface glycoproteins the virus causes annual epidemics with severe morbidity and mortality. Although hemagglutinin (HA) is one of the highly variable surface glycoproteins of the influenza virus, it remains the most attractive target for vaccine development against seasonal influenza infection because antibodies generated against HA provide virus neutralization and subsequent protection against the virus infection. Combination of recombinant adenovirus (rAd) vector-based vaccine and mucosal administration is a promising regimen for safe and effective vaccination against influenza. In this study, we constructed rAd encoding the globular head region of HA from A/Puerto Rico/8/34 virus as vaccine candidate. The rAd vaccine was engineered to express high level of the protein in secreted form. Intranasal or sublingual immunization of mice with the rAd-based vaccine candidates induced significant levels of sustained HA-specific mucosal IgA and IgG. When challenged with lethal dose of homologous virus, the vaccinated mice were completely protected from the infection. The results demonstrate that intranasal or sublingual vaccination with HA-encoding rAd elicits protective immunity against infection with homologous influenza virus. This finding underlines the potential of our recombinant adenovirusbased influenza vaccine candidate for both efficacy and rapid production.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Collin, N / 2009 / Vaccine production capacity for seasonal and pandemic (H1N1) 2009 influenza / Vaccine 27 : 5184 ~ 5186
2. [학술지(정기간행물)] - Shirakawa, T. / 2009 / Clinical trial design for adenoviral gene therapy products / Drug News Perspect 22 : 140 ~ 145
3. [학술지(정기간행물)] - Muruve, D. A. / 2004 / The innate immune response to adenovirus vectors / Hum. Gene Ther 15 : 1157 ~ 1166
4. [학술지(정기간행물)] - Zhu, J. / 2007 / Innate immune response to adenoviral vectors is mediated by both Toll-like receptor- dependent and -independent pathways / J. Virol 81 : 3170 ~ 3180
5. [학술지(정기간행물)] - Nociari, M. / 2007 / Sensing infection by adenovirus: Toll-like receptor- independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator / J. Virol 81 : 4145 ~ 4157
2. [학술지(정기간행물)] - Shirakawa, T. / 2009 / Clinical trial design for adenoviral gene therapy products / Drug News Perspect 22 : 140 ~ 145
3. [학술지(정기간행물)] - Muruve, D. A. / 2004 / The innate immune response to adenovirus vectors / Hum. Gene Ther 15 : 1157 ~ 1166
4. [학술지(정기간행물)] - Zhu, J. / 2007 / Innate immune response to adenoviral vectors is mediated by both Toll-like receptor- dependent and -independent pathways / J. Virol 81 : 3170 ~ 3180
5. [학술지(정기간행물)] - Nociari, M. / 2007 / Sensing infection by adenovirus: Toll-like receptor- independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator / J. Virol 81 : 4145 ~ 4157
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UCI(KEPA) : I410-ECN-0101-2016-511-001746013