지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 257 - 263 (7page)
이용수
초록· 키워드
오류제보하기
Although pathogenesis of human rheumatoid arthritis (RA) remains unclear, arthritogenic T cells and downstream signaling mediators have been shown to play critical roles. An increasing numbers of therapeutic options have been added for the effective control of RA. Nevertheless, there is still a category of patients that fails treatment and suffers from progressive disease. The recently developed immunosuppressant CP-690550, a small molecule JAK kinase inhibitor, has been implicated as an important candidate treatment modality for autoimmune arthritis. In this study, we evaluated the therapeutic effect of CP-690550 on established arthritis using an SKG arthritis model, a pathophysiologically relevant animal model for human RA. CP-690550 treatment revealed remarkable long-term suppressive effects on SKG arthritis when administered to the well-advanced disease (clinical score 3.5∼4.0). The treatment effect lasted at least 3 more weeks after cessation of drug infusion, and suppression of disease was correlated with the reduced pro-inflammatory cytokines, including IL-17, IFN-γ, and IL-6 and increased level of immunoregulatory IL-10.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Firestein, G. S. / 2005 / Immunologic mechanisms in the pathogenesis of rheumatoid arthritis / J. Clin. Rheumatol 11 : S39 ~ S44
2. [학술지(정기간행물)] - VanderBorght, A. / 2001 / The autoimmune pathogenesis of rheumatoid arthritis: role of autoreactive T cells and new immunotherapies / Semin. Arthritis Rheum 31 : 160 ~ 175
3. [학술지(정기간행물)] - McInnes, I. B / 2007 / Cytokines in the pathogenesis of rheumatoid arthritis / Nat. Rev. Immunol 7 : 429 ~ 442
4. [학술지(정기간행물)] - Firestein, G. S / 2003 / Evolving concepts of rheumatoid arthritis / Nature 423 : 356 ~ 361
5. [학술지(정기간행물)] - Fournier, C / 2005 / Where do T cells stand in rheumatoid arthritis? / Joint Bone Spine 72 : 527 ~ 532
2. [학술지(정기간행물)] - VanderBorght, A. / 2001 / The autoimmune pathogenesis of rheumatoid arthritis: role of autoreactive T cells and new immunotherapies / Semin. Arthritis Rheum 31 : 160 ~ 175
3. [학술지(정기간행물)] - McInnes, I. B / 2007 / Cytokines in the pathogenesis of rheumatoid arthritis / Nat. Rev. Immunol 7 : 429 ~ 442
4. [학술지(정기간행물)] - Firestein, G. S / 2003 / Evolving concepts of rheumatoid arthritis / Nature 423 : 356 ~ 361
5. [학술지(정기간행물)] - Fournier, C / 2005 / Where do T cells stand in rheumatoid arthritis? / Joint Bone Spine 72 : 527 ~ 532
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UCI(KEPA) : I410-ECN-0101-2016-511-001745990