지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 249 - 256 (8page)
이용수
초록· 키워드
오류제보하기
How Th2 immunity develops in vivo remains obscure. Basophils have been considered key innate cells producing IL-4, a cytokine essential for Th2 immunity. Increasing evidence suggests that basophils are dispensable for the initiation of Th2 immunity. In this study, we revisited the role of basophils in Th2 immune responses induced by various types of adjuvants. Mice deficient in IL-3 or IL-3 receptor, in which basophil lymph node recruitment is completely abolished, fully developed wild type level Th2 CD4 T cell responses in response to parasite antigen or papain immunization. Similar finding was also observed in mice where basophils are inducibly ablated. Interestingly, IL-4-derived from non-T cells appeared to be critical for the generation of IL-4-producing CD4 T cells. Other Th2 promoting factors including IL-25 and thymic stromal lymphopoietin (TSLP) were dispensable. Therefore, our results suggest that IL-3- and basophil-independent in vivo Th2 immunity develops with the help of non-T cell-derived IL-4, offering an additional mechanism by which Th2 type immune responses arise in vivo.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Karasuyama, H. / 2011 / Nonredundant roles of basophils in immunity / Annu. Rev. Immunol 29 : 45 ~ 69
2. [학술지(정기간행물)] - Min, B. / 2008 / Basophils: what they ‘can do’ versus what they ‘actually do’ / Nat. Immunol 9 : 1333 ~ 1339
3. [학술지(정기간행물)] - Sokol, C. L. / 2010 / Role of basophils in the initiation of Th2 responses / Curr. Opin. Immunol 22 : 73 ~ 77
4. [학술지(정기간행물)] - Siracusa, M. C. / 2010 / New paradigms in basophil development, regulation and function. Immunol / Cell. Biol 88 : 275 ~ 284
5. [학술지(정기간행물)] - Nakanishi, K. / 2010 / Basophils as APC in Th2 response in allergic inflammation and parasite infection / Curr. Opin. Immunol 22 : 814 ~ 820
2. [학술지(정기간행물)] - Min, B. / 2008 / Basophils: what they ‘can do’ versus what they ‘actually do’ / Nat. Immunol 9 : 1333 ~ 1339
3. [학술지(정기간행물)] - Sokol, C. L. / 2010 / Role of basophils in the initiation of Th2 responses / Curr. Opin. Immunol 22 : 73 ~ 77
4. [학술지(정기간행물)] - Siracusa, M. C. / 2010 / New paradigms in basophil development, regulation and function. Immunol / Cell. Biol 88 : 275 ~ 284
5. [학술지(정기간행물)] - Nakanishi, K. / 2010 / Basophils as APC in Th2 response in allergic inflammation and parasite infection / Curr. Opin. Immunol 22 : 814 ~ 820
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UCI(KEPA) : I410-ECN-0101-2016-511-001745985