지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 277 - 288 (12page)
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초록· 키워드
오류제보하기
T cells are central players in the regulation of adaptive immunity and immune tolerance. In the periphery, T cell differentiation for maturation and effector function is regulated by a number of factors. Various factors such as antigens, co-stimulation signals, and cytokines regulate T cell differentiation into functionally specialized effector and regulatory T cells. Other factors such as nutrients, micronutrients, nuclear hormones and microbial products provide important environmental cues for T cell differentiation. A mounting body of evidence indicates that the microbial metabolites shortchain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation. We review the current status of our understanding of SCFA functions in regulation of peripheral T cell activity and discuss their impact on tissue inflammation.
목차
INTRODUCTION
ORIGIN, PRODUCTION, TRANSPORT, AND RECEPTORS OF SCFAs
BASIC FUNCTIONS OF SCFAs IN THE BODY
COMPLEX ROLES OF SCFAs IN REGULATION OF EFFECTOR VERSUS REGULATORY T CELLS
POTENTIAL MECHANISMS FOR THE REGULATORY EFFECT OF SCFAs ON T CELLS
REGULATION OF TISSUE INFLAMMATION BY SCFAs
CONCLUDING REMARKS
REFERENCES
참고문헌 (128)
참고문헌 신청
1. [학술지(정기간행물)] - Heinonen, K. M / 2008 / Development and functional properties of thymic and extrathymic T lymphocytes / Crit. Rev. Immunol 28 : 441 ~ 466
2. [학술지(정기간행물)] - Bhandoola, A / 2007 / Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from / Immunity 26 : 678 ~ 689
3. [학술지(정기간행물)] - Gapin, L / 2014 / Check MAIT / J. Immunol 192 : 4475 ~ 4480
4. [학술지(정기간행물)] - Rossjohn, J. / 2012 / Recognition of CD1d-restricted antigens by natural killer T cells / Nat. Rev. Immunol 12 : 845 ~ 857
5. [학술지(정기간행물)] - Wan, Y. Y. / 2010 / Multi-tasking of helper T cells / Immunology 130 : 166 ~ 171
2. [학술지(정기간행물)] - Bhandoola, A / 2007 / Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from / Immunity 26 : 678 ~ 689
3. [학술지(정기간행물)] - Gapin, L / 2014 / Check MAIT / J. Immunol 192 : 4475 ~ 4480
4. [학술지(정기간행물)] - Rossjohn, J. / 2012 / Recognition of CD1d-restricted antigens by natural killer T cells / Nat. Rev. Immunol 12 : 845 ~ 857
5. [학술지(정기간행물)] - Wan, Y. Y. / 2010 / Multi-tasking of helper T cells / Immunology 130 : 166 ~ 171
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UCI(KEPA) : I410-ECN-0101-2016-511-001754188