지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 156 - 163 (8page)
이용수
초록· 키워드
오류제보하기
Interleukin (IL) 17 is produced by T-helper (Th) 17 with a vigorous effect on cells of the immune system playing important roles in pathogenesis of immune-mediated diseases, including autoimmune disorders and cancers. Therefore, the aim of current study was to determine the serum levels of IL-6, IL-17, and transforming growth factor beta (TGF-β) in Iranian bladder cancer patients, and to correlate them with disease status. Blood samples were collected from 40 bladder cancer patients and 38 healthy individuals with no history of malignancies or autoimmune disorders. The serum levels of IL-6, IL-17, and TGF-β were measured by the enzyme-linked immunosorbent assay (ELISA). The results showed that the levels of IL-17 and TGF-β were significantly lower in the patients compared to the controls. No significant differences in the level of serum IL-6 (p=0.16) was observed between the patients and controls. In addition, demographic characteristics between control and patients groups were not significantly different. As most of the cases studied in this investigation were in stage I and II, it is concluded that reduced Th17-related cytokines can be used as indicators for following the course and clinical stages of bladder carcinoma progress and immune response to cancer.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Mosmann, T. R. / 2005 / Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins / J. Immunol 175 : 5 ~ 14
2. [학술지(정기간행물)] - Park, H. / 2005 / A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 / Nat. Immunol 6 : 1133 ~ 1141
3. [학술지(정기간행물)] - Annunziato / 2007 / Phenotypic and functional features of human Th17 cells / J. Exp. Med 204 : 1849 ~ 1861
4. [학술지(정기간행물)] - Peck, A. / 2009 / Breaking old paradigms: Th17 cells in autoimmune arthritis / Clin. Immunol 132 : 295 ~ 304
5. [학술지(정기간행물)] - Sfanos, K. S / 2008 / Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing / Clin. Cancer Res 14 : 3254 ~ 3261
2. [학술지(정기간행물)] - Park, H. / 2005 / A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 / Nat. Immunol 6 : 1133 ~ 1141
3. [학술지(정기간행물)] - Annunziato / 2007 / Phenotypic and functional features of human Th17 cells / J. Exp. Med 204 : 1849 ~ 1861
4. [학술지(정기간행물)] - Peck, A. / 2009 / Breaking old paradigms: Th17 cells in autoimmune arthritis / Clin. Immunol 132 : 295 ~ 304
5. [학술지(정기간행물)] - Sfanos, K. S / 2008 / Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing / Clin. Cancer Res 14 : 3254 ~ 3261
이 논문의 저자 정보
최근 본 자료
댓글(0)
0