지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 138 - 148 (11page)
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초록· 키워드
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MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.
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참고문헌 (87)
참고문헌 신청
1. [학술지(정기간행물)] - Carthew, R. W. / 2009 / Origins and Mechanisms of miRNAs and siRNAs / Cell 136 : 642 ~ 655
2. [학술지(정기간행물)] - Kim, V. N. / 2009 / Biogenesis of small RNAs in animals / Nat. Rev. Mol. Cell Biol 10 : 126 ~ 139
3. [학술지(정기간행물)] - Inui, M. / 2010 / MicroRNA control of signal transduction / Nat. Rev. Mol. Cell Biol 11 : 252 ~ 263
4. [학술지(정기간행물)] - Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136 : 215 ~ 233
5. [학술지(정기간행물)] - Chen, C. Z. / 2004 / MicroRNAs modulate hematopoietic lineage differentiation / Science 303 : 83 ~ 86
2. [학술지(정기간행물)] - Kim, V. N. / 2009 / Biogenesis of small RNAs in animals / Nat. Rev. Mol. Cell Biol 10 : 126 ~ 139
3. [학술지(정기간행물)] - Inui, M. / 2010 / MicroRNA control of signal transduction / Nat. Rev. Mol. Cell Biol 11 : 252 ~ 263
4. [학술지(정기간행물)] - Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136 : 215 ~ 233
5. [학술지(정기간행물)] - Chen, C. Z. / 2004 / MicroRNAs modulate hematopoietic lineage differentiation / Science 303 : 83 ~ 86
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