지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 128 - 137 (10page)
이용수
초록· 키워드
오류제보하기
Respiratory viruses can induce acute respiratory disease. Clinical symptoms and manifestations are dependent on interactions between the virus and host immune system. Dendritic cells (DCs), along with alveolar macrophages, constitute the first line of sentinel cells in the innate immune response against respiratory viral infection. DCs play an essential role in regulating the immune response by bridging innate and adaptive immunity. In the steady state, lung DCs can be subdivided into CD103<sup>+</sup> conventional DCs (cDCs), CD11b<sup>+</sup> cDCs, and plasmacytoid DCs (pDCs). In the inflammatory state, like a respiratory viral infection, monocyte-derived DCs (moDCs) are recruited to the lung. In inflammatory lung, discrimination between moDCs and CD11b<sup>+</sup> DCs in the inflamed lung has been a critical challenge in understanding their role in the antiviral response. In particular, CD103<sup>+</sup> cDCs migrate from the intraepithelial base to the draining mediastinal lymph nodes to primarily induce the CD8<sup>+</sup> T cell response against the invading virus. Lymphoid CD8α<sup>+</sup> cDCs, which have a developmental relationship with CD103<sup>+</sup> cDCs, also play an important role in viral antigen presentation. Moreover, pDCs have been reported to promote an antiviral response by inducing type I interferon production rather than adaptive immunity. However, the role of these cells in respiratory infections remains unclear. These different DC subsets have functional specialization against respiratory viral infection. Under certain viral infection, contextually controlling the balance of these specialized DC subsets is important for an effective immune response and maintenance of homeostasis.
목차
등록된 정보가 없습니다.
참고문헌 (89)
참고문헌 신청
1. [학술지(정기간행물)] - De Heer, H. J / 2005 / Dendritic cell subsets and immune regulation in the lung / Semin. Immunol 17 : 295 ~ 303
2. [학술지(정기간행물)] - Neyt, K / 2013 / The role of lung dendritic cell subsets in immunity to respiratory viruses / Immunol. Rev 255 : 57 ~ 67
3. [학술지(정기간행물)] - Guilliams, M. / 2013 / Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections / Mucosal Immunol 6 : 464 ~ 473
4. [학술지(정기간행물)] - Johnson, T. R. / 2011 / Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus / PLoS One 6 : e16458 ~
5. [학술지(정기간행물)] - 김태훈 / 2014 / Innate immune recognition of respiratory syncytial virus infection / BMB Reports 47 (4) : 184 ~ 191
2. [학술지(정기간행물)] - Neyt, K / 2013 / The role of lung dendritic cell subsets in immunity to respiratory viruses / Immunol. Rev 255 : 57 ~ 67
3. [학술지(정기간행물)] - Guilliams, M. / 2013 / Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections / Mucosal Immunol 6 : 464 ~ 473
4. [학술지(정기간행물)] - Johnson, T. R. / 2011 / Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus / PLoS One 6 : e16458 ~
5. [학술지(정기간행물)] - 김태훈 / 2014 / Innate immune recognition of respiratory syncytial virus infection / BMB Reports 47 (4) : 184 ~ 191
이 논문의 저자 정보
최근 본 자료
댓글(0)
0