지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 116 - 122 (7page)
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초록· 키워드
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Macrophage death plays a role in several physiological and inflammatory pathologies such as sepsis and arthritis. In our previous work, we showed that simvastatin triggers cell death in LPS-activated RAW 264.7 mouse macrophage cells through both caspase-dependent and independent apoptotic pathways. Here, we show that the nuclear orphan receptor NR4A1 is involved in a caspase-independent apoptotic process induced by LPS and simvastatin. Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. Furthermore, apoptosis was accompanied by Bcl-2-associated X protein (Bax) translocation to the mitochondria. Our findings suggest that NR4A1 expression and mitochondrial translocation of Bax are related to simvastatin-induced apoptosis in LPS-activated RAW 264.7 macrophages.
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참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Goldstein, J. L. / 1990 / Regulation of the mevalonate pathway / Nature 343 : 425 ~ 430
2. [학술지(정기간행물)] - Cordle, A. / 2005 / Mechanisms of statin-mediated inhibition of small G-protein function / J. Biol. Chem 280 : 34202 ~ 34209
3. [학술지(정기간행물)] - Massy, Z. A. / 1996 / Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction? / Lancet 347 : 102 ~ 103
4. [학술지(정기간행물)] - Sacks, F. M. / 1998 / Relationship between plasma LDL concentrations during treatment with pravastatin and recurrent coronary events in the Cholesterol and Recurrent Events trial / Circulation 97 : 1446 ~ 1452
5. [학술지(정기간행물)] - Ridker, P. M. / 1999 / Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators / Circulation 100 : 230 ~ 235
2. [학술지(정기간행물)] - Cordle, A. / 2005 / Mechanisms of statin-mediated inhibition of small G-protein function / J. Biol. Chem 280 : 34202 ~ 34209
3. [학술지(정기간행물)] - Massy, Z. A. / 1996 / Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction? / Lancet 347 : 102 ~ 103
4. [학술지(정기간행물)] - Sacks, F. M. / 1998 / Relationship between plasma LDL concentrations during treatment with pravastatin and recurrent coronary events in the Cholesterol and Recurrent Events trial / Circulation 97 : 1446 ~ 1452
5. [학술지(정기간행물)] - Ridker, P. M. / 1999 / Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators / Circulation 100 : 230 ~ 235
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