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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 81 - 88 (8page)
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초록· 키워드
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Mesenchymal stem cells (MSCs) are present in diverse tissues and organs, including bone marrow, umbilical cord, adipose tissue, and placenta. MSCs can expand easily in vitro and have regenerative stem cell properties and potent immunoregulatory activity. They inhibit the functions of dendritic cells, B cells, and T cells, but enhance those of regulatory T cells by producing immunoregulatory molecules such as transforming growth factor-β, hepatic growth factors, prostaglandin E<sub>2</sub>, interleukin-10, indolamine 2,3-dioxygenase, nitric oxide, heme oxygenase-1, and human leukocyte antigen-G. These properties make MSCs promising therapeutic candidates for the treatment of autoimmune diseases. Here, we review the preclinical studies of MSCs in animal models for systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease, and experimental autoimmune encephalomyelitis, and summarize the underlying immunoregulatory mechanisms.
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참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Watt, F. M. / 2000 / Out of Eden : stem cells and their niches / Science 287 : 1427 ~ 1430
2. [학술지(정기간행물)] - Thomson, J. A. / 1998 / Embryonic stem cell lines derived from human blastocysts / Science 282 : 1145 ~ 1147
3. [학술지(정기간행물)] - Friedenstein, A. J. / 1970 / The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells / Cell Tissue Kinet 3 : 393 ~ 403
4. [학술지(정기간행물)] - Nussbaum, J. / 2007 / Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response / FASEB. J 21 : 1345 ~ 1357
5. [학술지(정기간행물)] - Kon, E / 2000 / Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones / J. Biomed. Mater. Res 49 : 328 ~ 337
2. [학술지(정기간행물)] - Thomson, J. A. / 1998 / Embryonic stem cell lines derived from human blastocysts / Science 282 : 1145 ~ 1147
3. [학술지(정기간행물)] - Friedenstein, A. J. / 1970 / The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells / Cell Tissue Kinet 3 : 393 ~ 403
4. [학술지(정기간행물)] - Nussbaum, J. / 2007 / Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response / FASEB. J 21 : 1345 ~ 1357
5. [학술지(정기간행물)] - Kon, E / 2000 / Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones / J. Biomed. Mater. Res 49 : 328 ~ 337
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