지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 73 - 80 (8page)
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초록· 키워드
오류제보하기
Because autoimmune diseases (AIDs) result from a complex combination of genetic and epigenetic factors, as well as an altered immune response to endogenous or exogenous antigens, systems biology approaches have been widely applied. The use of multi-omics approaches, including blood transcriptomics, genomics, epigenetics, proteomics, and metabolomics, not only allow for the discovery of a number of biomarkers but also will provide new directions for further translational AIDs applications. Systems biology approaches rely on high-throughput techniques with data analysis platforms that leverage the assessment of genes, proteins, metabolites, and network analysis of complex biologic or pathways implicated in specific AID conditions. To facilitate the discovery of validated and qualified biomarkers, better-coordinated multi-omics approaches and standardized translational research, in combination with the skills of biologists, clinicians, engineers, and bioinformaticians, are required.
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등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
1. [학술지(정기간행물)] - Whitacre, C. C. / 2001 / Sex differences in autoimmune disease / Nat. Immunol 2 : 777 ~ 780
2. [학술지(정기간행물)] - Blumberg, R. S. / 2012 / Unraveling the autoimmune translational research process layer by layer / Nat. Med 18 : 35 ~ 41
3. [학술지(정기간행물)] - Goldblatt, F / 2013 / Clinical aspects of autoimmune rheumatic diseases / Lancet 382 : 797 ~ 808
4. [학술지(정기간행물)] - Trowsdale, J. / 2011 / The MHC, disease and selection / Immunol. Lett 137 : 1 ~ 8
5. [학술지(정기간행물)] - Nocturne, G / 2013 / Advances in understanding the pathogenesis of primary Sjogren's syndrome / Nat. Rev. Rheumatol 9 : 544 ~ 556
2. [학술지(정기간행물)] - Blumberg, R. S. / 2012 / Unraveling the autoimmune translational research process layer by layer / Nat. Med 18 : 35 ~ 41
3. [학술지(정기간행물)] - Goldblatt, F / 2013 / Clinical aspects of autoimmune rheumatic diseases / Lancet 382 : 797 ~ 808
4. [학술지(정기간행물)] - Trowsdale, J. / 2011 / The MHC, disease and selection / Immunol. Lett 137 : 1 ~ 8
5. [학술지(정기간행물)] - Nocturne, G / 2013 / Advances in understanding the pathogenesis of primary Sjogren's syndrome / Nat. Rev. Rheumatol 9 : 544 ~ 556
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