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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.2
- 수록면
- 30 - 37 (8page)
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Collaboration of TLR and non-TLR pathways in innate immune cells, which acts in concert for the induction of inflammatory cytokines, can mount a specific adaptive immune response tailored to a pathogen. Here, we show that murine DC produced increased IL-23 and IL-6 when they were treated with LPS together with curdlan that activates TLR4 and dectin-1, respectively. We also found that the induction of the inflammatory cytokine production by LPS and curdlan requires activation of IKK. However, the same treatment did not induce DC to produce a sufficient amount of TGF-β. As a result, the conditioned media from DC treated with LPS and curdlan was not able to direct CD4<sup>+</sup> T cells to Th17 cells. Addition of TGF-β but not IL-6 or IL-1β was able to promote IL-17 production from CD4<sup>+</sup> T cells. Our results showed that although signaling mediated by LPS together with curdlan is a potent stimulator of DC to secrete many pro-inflammatory cytokines, TGF-β production is a limiting factor for promoting Th17 immunity.
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참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Palm, N. W. / 2009 / Pattern recognition receptors and control of adaptive immunity / Immunol. Rev 227 : 221 ~ 233
2. [학술지(정기간행물)] - Hollmig, S. T. / 2009 / Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2 / Glycobiology 19 : 568 ~ 575
3. [학술지(정기간행물)] - Brikos, C / 2008 / Signalling of toll-like receptors / Handb. Exp. Pharmacol : 21 ~ 50
4. [학술지(정기간행물)] - Taylor, P. R / 2007 / Dectin-1 is required for beta-glucan recognition and control of fungal infection / Nat. Immunol 8 : 31 ~ 38
5. [학술지(정기간행물)] - Saijo, S / 2007 / Dectin-1is required for host defense against Pneumocystis carinii but not against Candida albicans / Nat. Immunol 8 : 39 ~ 46
2. [학술지(정기간행물)] - Hollmig, S. T. / 2009 / Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2 / Glycobiology 19 : 568 ~ 575
3. [학술지(정기간행물)] - Brikos, C / 2008 / Signalling of toll-like receptors / Handb. Exp. Pharmacol : 21 ~ 50
4. [학술지(정기간행물)] - Taylor, P. R / 2007 / Dectin-1 is required for beta-glucan recognition and control of fungal infection / Nat. Immunol 8 : 31 ~ 38
5. [학술지(정기간행물)] - Saijo, S / 2007 / Dectin-1is required for host defense against Pneumocystis carinii but not against Candida albicans / Nat. Immunol 8 : 39 ~ 46
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