지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 284 - 290 (7page)
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초록· 키워드
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Innate immune cells sense and respond to the cytoplasmic infection of bacterial pathogens through NLRP3, NLRC4 or AIM2 inflammasome depending on the unique molecular pattern of invading pathogens. The infection of flagellin- or type III secretion system (T3SS)-containing Gram-negative bacteria such as Salmonella enterica serovar Typhimurium (S. typhimurium) or Pseudomonas aeruginosa (P. aeruginosa) triggers NLRC4-dependent caspase-1 activation leading to the secretion of proinflammatory cytokines such as interleukin-1-beta (IL-1β) and IL-18. Previous studies have shown that apoptosis-associated speck-like protein containing a CARD (ASC) is also required for Salmonella-induced caspase-1 activation, but it is still unclear how ASC contributes to the activation of NLRC4 inflammasome in response to S. typhimurium infection. In this study, we demonstrate that S. typhimurium triggers the formation of ASC oligomer in a potassium depletion-independent manner as determined by in vitro crosslinking and in situ fluorescence imaging. Remarkably, inhibition of potassium efflux failed to block Salmonella-promoted caspase-1 activation and macrophage cell death. These results collectively suggest that ASC is substantially oligomerized to facilitate the activation of caspase-1 in response to S. typhimurium infection. Contrary to NLRP3 inflammasome, intracellular potassium depletion is not critical for NLRC4 inflammasome signaling by S. typhimurium.
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참고문헌 (23)
참고문헌 신청
Strowig, T. / 2012 / Inflammasomes in health and disease / Nature 481:278~286
Sujeong Hong / 2011 / Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity / Journal of Bacteriology and Virology 41(3):133~146
유제욱 / 200709 / The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation / CELL DEATH AND DIFFERENTIATION 14(9):1590~1604
Fernandes-Alnemri, T. / 200903 / AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA / NATURE 458(7237):509~5
Elinav, E. / 2011 / Regulation of the antimicrobial response by NLRproteins / Immunity 34:665~679
Sujeong Hong / 2011 / Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity / Journal of Bacteriology and Virology 41(3):133~146
유제욱 / 200709 / The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation / CELL DEATH AND DIFFERENTIATION 14(9):1590~1604
Fernandes-Alnemri, T. / 200903 / AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA / NATURE 458(7237):509~5
Elinav, E. / 2011 / Regulation of the antimicrobial response by NLRproteins / Immunity 34:665~679
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