지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 223 - 229 (7page)
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초록· 키워드
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Clinical and preclinical in vivo immune cell imaging approaches have been used to study immune cell proliferation, apoptosis and interaction at the microscopic (intra-vital imaging) and macroscopic (whole-body imaging) level by use of ex vivo or in vivo labeling method. A series of imaging techniques ranging from non-radiation based techniques such as optical imaging, MRI, and ultrasound to radiation based CT/nuclear imaging can be used for in vivo immune cell tracking. These imaging modalities highlight the intrinsic behavior of different immune cell populations in physiological context. Fluorescent, radioactive or paramagnetic probes can be used in direct labeling protocols to monitor the specific cell population. Reporter genes can also be used for genetic, indirect labeling protocols to track the fate of a given cell subpopulation in vivo. In this review, we summarized several methods dealing with dendritic cell, macrophage, and T lymphocyte specifically labeled for different macroscopic whole-body imaging techniques both for the study of their physiological function and in the context of immunotherapy to exploit imaging-derived information and immune-based treatments.
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참고문헌 (26)
참고문헌 신청
Blasberg, R. G. / 2002 / In vivo molecular- genetic imaging / J. Cell. Biochem. Suppl 39:172~183
Forss-Petter, S. / 1990 / Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control / Neuron 5:187~197
Yu, Y. A. / 2003 / Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals / Anal. Bioanal. Chem 377:964~972
Shaner, N. C / 2005 / A guide to choosing fluorescent proteins / Nat. Methods 2:905~909
Tjuvajev, J. G / 1995 / Imaging the expression of transfected genes in vivo / Cancer Res 55:6126~6132
Forss-Petter, S. / 1990 / Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control / Neuron 5:187~197
Yu, Y. A. / 2003 / Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals / Anal. Bioanal. Chem 377:964~972
Shaner, N. C / 2005 / A guide to choosing fluorescent proteins / Nat. Methods 2:905~909
Tjuvajev, J. G / 1995 / Imaging the expression of transfected genes in vivo / Cancer Res 55:6126~6132
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