지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 213 - 216 (4page)
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초록· 키워드
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Our previous report showed that polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense has anti-inflammatory activity. In this study we investigated the role of the PA as inhibitor of caspase-1, which converts prointerleukin-1β (proIL-1β) to active IL-1β and is activated by inflammasome involved in the inflammatory process. We tested the effect of PA on the production of pro-inflammatory cytokines, IL-1β in murine macrophage cell line, RAW264.7. PA inhibited lipopolysaccharide (LPS)-induced IL-1β production by macrophages at a dose dependent manner. PA also suppressed the activation of caspase-1. The mRNA level of ASC (apoptosis-associated spec-like protein containing a CARD), an important adaptor protein of inflammasome, was decreased in the PA treated group. Therefore our results suggest that the anti-inflammatory effect of PA is due to inhibit the caspase-1 activation.
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참고문헌 (13)
참고문헌 신청
Philpott, D. J. / 2004 / The role of Toll-like receptors and Nod proteins in bacterial infection / Mol. Immunol 41:1099~1108
Franchi, L. / 2008 / Intracellular NOD-like receptors in innate immunity, infection and disease / Cell. Microbiol 10:1~8
Kanneganti, T. D. / 2007 / Intracellular NOD-like receptors in host defense and disease / Immunity 27:549~559
Kuida, K. / 1995 / Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme / Science 267:2000~2003
Mariathasan, S. / 2007 / Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation / Nat. Rev. Immunol 7:31~40
Franchi, L. / 2008 / Intracellular NOD-like receptors in innate immunity, infection and disease / Cell. Microbiol 10:1~8
Kanneganti, T. D. / 2007 / Intracellular NOD-like receptors in host defense and disease / Immunity 27:549~559
Kuida, K. / 1995 / Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme / Science 267:2000~2003
Mariathasan, S. / 2007 / Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation / Nat. Rev. Immunol 7:31~40
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