지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 207 - 212 (6page)
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초록· 키워드
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T cell immunoglobulin mucin domain (TIM)-3 is an immunomodulatory molecule and upregulated in T cells by several cytokines. TIM-3 also influences mast cell function but its transcriptional regulation in mast cells has not been clarified. Therefore, we examined the transcript level and the promoter activity of TIM-3 in mast cells. The TIM-3 transcript level was assessed by real-time RT-PCR and promoter activity by luciferase reporter assay. TIM-3 mRNA levels were increased in HMC-1, a human mast cell line by TGF-β1 stimulation but not by stimulation with interferon (IFN)-α, IFN-λ, TNF-α, or IL-10. TIM-3 promoter -349~+144 bp region relative to the transcription start site was crucial for the basal and TGF-β1-induced TIM-3 promoter activities in HMC-1 cells. TIM-3 promoter activity was increased by over-expression of Smad2 and Smad4, downstream molecules of TGF-β1 signaling. Our results localize TIM-3 promoter activity to the region spanning -349 to ＋144 bp in resting and TGF-β1 stimulated mast cells.
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참고문헌 (23)
참고문헌 신청
Sakuishi, K. / 2011 / Emerging Tim-3 functions in antimicrobial and tumor immunity / Trends Immunol 32:345~349
Sakuishi, K. / 2010 / Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti- tumor immunity / J. Exp. Med 207:2187~2194
Zhou, Q. / 2011 / Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia / Blood 117:4501~4510
Lee, M. J. / 201210 / Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription / IMMUNOBIOLOGY 217(10):986~995
Chiba, S. / 2012 / Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1 / Nat. Immunol 13:832~842
Sakuishi, K. / 2010 / Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti- tumor immunity / J. Exp. Med 207:2187~2194
Zhou, Q. / 2011 / Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia / Blood 117:4501~4510
Lee, M. J. / 201210 / Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription / IMMUNOBIOLOGY 217(10):986~995
Chiba, S. / 2012 / Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1 / Nat. Immunol 13:832~842
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