지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 196 - 206 (11page)
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초록· 키워드
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Besides their role as building blocks of protein, there are growing evidences that some amino acids have roles in regulating key metabolic pathways that are necessary for maintenance, growth, reproduction, and immunity. Here, we evaluated the modulatory functions of several amino acids in protective immunity against mucosal infection of herpes simplex virus type 1 (HSV-1). We found that glutamine (Gln) and leucine (Leu) showed enhanced protective immunity to HSV-1 mucosal infection when two administration of Gln and single administration of Leu per day, but not when administered in combinations. Ameliorated clinical signs of HSV-1 challenged mice by the intraperitoneal administration of Gln and Leu were closely associated with viral burden and IFN-γ production in the vaginal tract at 2 and 4 days post-infection. In addition, the enhanced production of vaginal IFN-γ appeared to be caused by NK and HSV-1 antigen-specific Th1-type CD4+ T cells recruited into vaginal tract of mice treated with Gln and Leu, which indicates that IFN-γ, produced by NK and Th1-type CD4+ T cells, may be critical to control the outcome of diseases caused by HSV-1 mucosal infection. Collectively, our results indicate that intraperitoneal administration of Gln and Leu following HSV-1 mucosal infection could provide beneficial effects for the modulation of protective immunity, but dosage and frequency of administration should be carefully considered, because higher frequency and overdose of Gln and Leu, or their combined treatment, showed detrimental effects to protective immunity.
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참고문헌 (37)
참고문헌 신청
Wu, G / 2009 / Amino acids: metabolism, functions, and nutrition / Amino Acids 37:1~17
Suenaga, R. / 2008 / Intracerebroventricular injection of L-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks / Amino Acids 35:139~146
Wu, G. / 2007 / Important roles for the arginine family of amino acids in swine nutrition and production / Livest. Sci 112:8~22
Wu, G. / 2007 / Pharmacokinetics and safety of arginine supplementation in animals / J. Nutr 137(6):1673S~1680S
Wu, G. / 2007 / Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats / J. Nutr 137:2680~2685
Suenaga, R. / 2008 / Intracerebroventricular injection of L-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks / Amino Acids 35:139~146
Wu, G. / 2007 / Important roles for the arginine family of amino acids in swine nutrition and production / Livest. Sci 112:8~22
Wu, G. / 2007 / Pharmacokinetics and safety of arginine supplementation in animals / J. Nutr 137(6):1673S~1680S
Wu, G. / 2007 / Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats / J. Nutr 137:2680~2685
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