지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 113 - 117 (5page)
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FasL, perforin, TNFα, IL-1 and NO have been considered as effector molecule(s) leading to β-cell death in autoimmune diabetes. However, the real culprit(s) of β-cell destruction have long been elusive despite intense investigation. Previously we have suggested IFNγ/TNFα synergism as the final effector molecules in autoimmune diabetes of NOD mice. A combination of IFNγ and TNFα but neither cytokine alone, induced classical caspase-dependent apoptosis in murine insulinoma and pancreatic islet cells. IFNγ treatment conferred susceptibility to TNFα-induced apoptosis on otherwise resistant murine insulinoma cells by STAT1 activation followed by IRF-1 induction. Here we report that IFNγ/TNFα synergism induces apoptosis of human pancreatic islet cells. We also observed STAT1 activation followed by IRF-1 induction by IFNγ treatment in human islet cells. Taken together, we suggest that IFNγ/TNFα synergism could be involved in human islet cell death in type 1 diabetes, similar to murine type 1 diabetes.
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참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Kim, S. / 200710 / Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice / DIABETES 56 (10) : 2561 ~ 2568
2. [학술지(정기간행물)] - Suk, K. / 2001 / IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death / J. Immunol 166 : 4481 ~ 4489
3. [학술지(정기간행물)] - Kim, H. S. / 2007 / TLR2 as a link between β-cell injury and initiation of autoimmune diabetes / Immunity 27 : 321 ~ 333
4. [학술지(정기간행물)] - Turley, S. / 2003 / Physiological beta cell death triggers priming of self-reactiveT cells by dendritic cells in a type-1 diabetes model / J. Exp. Med 198 : 1527 ~ 1537
5. [학술지(정기간행물)] - Wicker, L. S. / 1986 / Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice / Diabetes 35 : 855 ~ 860
2. [학술지(정기간행물)] - Suk, K. / 2001 / IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death / J. Immunol 166 : 4481 ~ 4489
3. [학술지(정기간행물)] - Kim, H. S. / 2007 / TLR2 as a link between β-cell injury and initiation of autoimmune diabetes / Immunity 27 : 321 ~ 333
4. [학술지(정기간행물)] - Turley, S. / 2003 / Physiological beta cell death triggers priming of self-reactiveT cells by dendritic cells in a type-1 diabetes model / J. Exp. Med 198 : 1527 ~ 1537
5. [학술지(정기간행물)] - Wicker, L. S. / 1986 / Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice / Diabetes 35 : 855 ~ 860
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