지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 104 - 112 (9page)
이용수
초록· 키워드
오류제보하기
Silica is one of the most abundant compounds found in nature. Immoderate exposure to crystalline silica has been linked to pulmonary disease and crystalline silica has been classified as a Group I carcinogen. Ultrafine (diameter <100 nm) silica particles may have different toxicological properties compared to larger particles. We evaluated the effect of ultrafine silica nanoparticles on mouse bone marrow-derived dendritic cells (BMDC) and murine dendritic cell line, DC2.4. The exposure of dendritic cells (DCs) to ultrafine silica nanoparticles showed a decrease in cell viability and an induction of cell death in size- and concentration-dependent manners. In addition, in order to examine the phenotypic changes of DCs following co-culture with silica nanoparticles, we added each sized-silica nanoparticle along with GM-CSF and IL-4 during and after DC differentiation. Expression of CD11c, a typical DC marker, and multiple surface molecules such as CD54, CD80, CD86, MHC class II, was changed by silica nanoparticles in a size-dependent manner. We also found that silica nanoparticles affect inflammatory response in DCs in vitro and in vivo. Finally, we found that p38 and NF-κB activation may be critical for the inflammatory response by silica nanoparticles. Our data demonstrate that ultrafine silica nanoparticles have cytotoxic effects on dendritic cells and immune modulation effects in vitro and in vivo.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Chen, M. / 2005 / Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles / Exp. Cell Res 305:51~62
Pan, Z. / 2009 / Adverse effects of titanium dioxide nanoparticles on human dermal fibroblasts and how to protect cells / Small 5:511~520
Foley, S. / 2002 / Biochem / Biophys. Res. Commun 294:116~119
Oberdörster, E / 2004 / Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass / Environ. Health Perspect 112:1058~1062
Vallhov, H. / 2007 / Mesoporous silica particles induce size dependent effects on human dendritic cells / Nano Lett 7:3576~3582
Pan, Z. / 2009 / Adverse effects of titanium dioxide nanoparticles on human dermal fibroblasts and how to protect cells / Small 5:511~520
Foley, S. / 2002 / Biochem / Biophys. Res. Commun 294:116~119
Oberdörster, E / 2004 / Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass / Environ. Health Perspect 112:1058~1062
Vallhov, H. / 2007 / Mesoporous silica particles induce size dependent effects on human dendritic cells / Nano Lett 7:3576~3582
이 논문의 저자 정보
최근 본 자료
댓글(0)
0