지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 406 - 411 (6page)
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초록· 키워드
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Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant Vαβ TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with conventional T cells in some functional aspects, they simultaneously produce large amount of Th1 and Th2 cytokines upon T-cell receptor (TCR) ligation. However, gene expression pattern in two types of cells has not been well characterized. Methods: we performed comparative microarray analyses of gene expression in murine iNKT cells and conventional CD4<sup>+</sup>CD25^- γδTCR^- T cells by using Gene Set Enrichment Analysis (GSEA) method. Results: Here, we describe profound differences in gene expression pattern between iNKT cells and conventional CD4<sup>+</sup>CD25^- γδTCR^- T cells. Conclusion: Our results provide new insights into the functional competence of iNKT cells and a better understanding of their various roles during immune responses.
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참고문헌 (13)
참고문헌 신청
Bendelac A / 1995 / CD1 recognition by mouse NK1+ T lymphocytes / Science 268:863~865
Chen H / 1997 / Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1 / J Immunol 159:2240~2249
Mendiratta SK / 1997 / CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4 / Immunity 6:469~477
Godfrey DI / 2010 / Raising the NKT cell family / Nat Immunol 11:197~206
Kim JH / 200511 / Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma / AMERICAN JOURNAL OF PATHOLOGY 167:1231~1241
Chen H / 1997 / Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1 / J Immunol 159:2240~2249
Mendiratta SK / 1997 / CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4 / Immunity 6:469~477
Godfrey DI / 2010 / Raising the NKT cell family / Nat Immunol 11:197~206
Kim JH / 200511 / Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma / AMERICAN JOURNAL OF PATHOLOGY 167:1231~1241
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