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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 309 - 323 (15page)
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초록· 키워드
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MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs of about 22 nucleotides that have recently emerged as important regulators of gene expression at the posttranscriptional level. Recent studies provided clear evidence that microRNAs are abundant in the lung, liver and kidney and modulate a diverse spectrum of their functions. Moreover, a large number of studies have reported links between alterations of miRNA homeostasis and pathological conditions such as infectious diseases, sickle cell disease and endometrium diseases as well as lung, liver and kidney diseases. As a consequence of extensive participation of miRNAs in normal functions, alteration and/or abnormalities in miRNAs should have importance in human diseases. Beside their important roles in patterning and development, miRNAs also orchestrated responses to pathogen infections. Particularly, emerging evidence indicates that viruses use their own miRNAs to manipulate both cellular and viral gene expression. Furthermore, viral infection can exert a profound impact on the host cellular miRNA expression profile, and several RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential. Here I briefly summarize the newly discovered roles of miRNAs in various human diseases including infectious diseases, sickle cell disease and enodmetrium diseases as well as lung, liver and kidney diseases.
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참고문헌 (100)
참고문헌 신청
Tili E / 2008 / Expression and function of micro-RNAs in immune cells during normal or disease state / Int J Med Sci 5:73~79
Slaby O / 2009 / MicroRNAs in colorectal cancer: translation of molecular biology into clinical application / Mol Cancer 8:102
Small EM / 2011 / Pervasive roles of microRNAs in cardiovascular biology / Nature 469:336~342
하대유 / 2011 / MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease / Immune Network 11(3):135~154
하대유 / 2011 / MicroRNAs in Human Diseases: From Autoimmune Diseases to Skin, Psychiatric and Neurodegenerative Diseases / Immune Network 11(5):227~244
Slaby O / 2009 / MicroRNAs in colorectal cancer: translation of molecular biology into clinical application / Mol Cancer 8:102
Small EM / 2011 / Pervasive roles of microRNAs in cardiovascular biology / Nature 469:336~342
하대유 / 2011 / MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease / Immune Network 11(3):135~154
하대유 / 2011 / MicroRNAs in Human Diseases: From Autoimmune Diseases to Skin, Psychiatric and Neurodegenerative Diseases / Immune Network 11(5):227~244
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