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자료유형
학술저널
저자정보
저널정보
대한면역학회 Immune Network Immune Network Vol.11 No.5
발행연도
2011.10
수록면
258 - 267 (10page)

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Current management strategies attempt to diagnose rheumatoid arthritis (RA) at an early stage. Transcription profiling is applied in the search for biomarkers for detecting early-stage disease. Even though gene profiling has been reported using several animal models of RA, most studies were performed after the development of active arthritis, and conducted only on the peripheral blood and joint. Therefore, we investigated gene expression during the initial phase of collagen-induced arthritis (CIA) before the arthritic features developed in the thymus in addition to the peripheral blood and synovium. Methods: For gene expression analysis using cDNA microarray technology, samples of thymus, blood, and synovium were collected from CIA, rats immunized only with type II collagen (Cll), rats immunized only with adjuvant, and unimmunized rats on days 4 and 9 after the first immunization. Arrays were scanned with an Illumina bead array. Results: Of the 21,910 genes in the array, 1,243 genes were differentially expressed at least 2-fold change in various organs of CIA compared to controls. Among the 1,243 genes, 8 encode T-cell receptors (TCRs), including CD3ε, CD3δ, CD3ζ, CD8α, and CD8β genes, which were down-regulated in CIA. The synovium was the organ in which the genes were differentially expressed between CIA and control group, and no difference were found in the thymus and blood. Further, we determined that the differential expression was affected by adjuvant more than Cll. The differential expression of genes as revealed by real-time RT-PCR, was in agreement with the microarray data. Conclusion: This study provides evidence that the genes encoding TCRs including CD3ε, CD3δ, CD3ζ, CD8α, and CD8β genes were down-regulated during the initial phase of CIA in the synovium of CIA. In addition, adjuvant played a greater role in the down-regulation of the CD3 complex compared to CII. Therefore, the down-regulation of TCR gene expression occurred dominantly by adjuvant could be involved in the pathogenesis of the early stage at CIA.
#Rheumatoid arthritis #Collagen induced arthritis #Gene expression #T-cell receptor

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참고문헌 (36)

참고문헌 신청
Firestein GS / 1992 / Rheumatoid Arthritis: A Disease of Disordered Immunity / Raven Press google schola Aho K / 1991 / Rheumatoid factors antedating clinical rheumatoid arthritis / J Rheumatol 18:1282~1284 google schola Cush JJ / 2007 / Early rheumatoid arthritis - is there a window of opportunity / J Rheumatol (Suppl) 80:1~7 google schola Durie FH / 1994 / Collagen-induced arthritis as a model of rheumatoid arthritis / Clin Immunol Immunopathol 73:11~18 google schola Brunsberg U / 1994 / Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis / Eur J Immunol 24:1698~1702 google schola

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