지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.10
- 수록면
- 253 - 257 (5page)
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초록· 키워드
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The active metabolite (1, 25- dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. In this study, variation in the VDR gene was investigated in Korean population with tuberculosis. Methods: We typed three VDR polymorphisms of restriction endonuclease sites for TaqI, BsmI and FokI in 155 patients with tuberculosis and 105 healthy volunteers. Results: The frequencies of FokI genotypes determined from TB patients were 29.13% for FF, 56.31% for Ff, and 14.56% for ff. We observed 1.4-fold increased prevalence of the Ff genotype in TB patients compared with normal healthy groups (p=0.0857). However, there was no significant association between the genotype groups, TB patient and normal control, for FokI polymorphism. There was also no significant association between VDR gene and tuberculosis in another polymorphism (BsmI and TaqI). Conclusion: Three polymorphisms (TaqI, BsmI and FokI) in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in Korean population.
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참고문헌 (20)
참고문헌 신청
Dorman SE / 1998 / Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection / J Clin Invest 101:2364~2369
Altare F / 1998 / Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency / Science 280:1432~1435
Wang LM / 1999 / HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy / Int J Lepr Other Mycobact Dis 67:403~408
Kim SJ / 1987 / HLA and leprosy in Koreans / Tissue Antigens 29:146~153
Bellamy R / 1998 / Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans / N Engl J Med 338:640~644
Altare F / 1998 / Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency / Science 280:1432~1435
Wang LM / 1999 / HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy / Int J Lepr Other Mycobact Dis 67:403~408
Kim SJ / 1987 / HLA and leprosy in Koreans / Tissue Antigens 29:146~153
Bellamy R / 1998 / Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans / N Engl J Med 338:640~644
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