지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 216 - 222 (7page)
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The ligand for CD137 (CD137L; also called 4-1BBL) is mainly expressed on activated APCs such as dendritic cells, B cells and macrophages. Even though CD137L functions as a trigger of the CD137 signaling pathway for T cell activation and expansion, engagement of CD137L can deliver a signal leading to the production of proinflammatory cytokines in macrophages. Methods: We generated cell-permeable TAT-CD137L cytoplasmic domain fusion protein (TAT-CD137Lct) and examined its ability to initiate the CD137L reverse signaling pathway. Results: Treatment of TAT-CD137Lct induced the production of high levels of IL-6 and TNF-α mRNAs and proteins in peritoneal macrophages. TAT-CD137Lct increased phosphorylation of Erk, p38 MAPK and Jnk, and activated transcription factors C/EBP and CREB. However, TAT-CD137Lct did not visibly affect the degradation of the inhibitor of NF-κB (IkBα). We further demonstrated that JNK activation was required for TAT-CD137Lct-induced production of TNF-α, while activation of Erk and p38 MAPK were involved in IL-6 and TNF-α production. Conclusion: Our results suggest that TATCD137Lct is an effective activator for the CD137L reverse signaling pathway.
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참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Eissner G / 2004 / Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system / Cytokine Growth Factor Rev 15 : 353 ~ 366
2. [학술지(정기간행물)] - Schwarz H / 2005 / Biological activities of reverse signal transduction through CD137 ligand / J Leukoc Biol 77 : 281 ~ 286
3. [학술지(정기간행물)] - Shao Z / 2011 / CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction / J Leukoc Biol 89 : 21 ~ 29
4. [학술지(정기간행물)] - Langstein J / 1998 / CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling / J Immunol 160 : 2488 ~ 2494
5. [학술지(정기간행물)] - Langstein J / 1999 / CD137 induces proliferation and endomitosis in monocytes / Blood 94 : 3161 ~ 3168
2. [학술지(정기간행물)] - Schwarz H / 2005 / Biological activities of reverse signal transduction through CD137 ligand / J Leukoc Biol 77 : 281 ~ 286
3. [학술지(정기간행물)] - Shao Z / 2011 / CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction / J Leukoc Biol 89 : 21 ~ 29
4. [학술지(정기간행물)] - Langstein J / 1998 / CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling / J Immunol 160 : 2488 ~ 2494
5. [학술지(정기간행물)] - Langstein J / 1999 / CD137 induces proliferation and endomitosis in monocytes / Blood 94 : 3161 ~ 3168
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