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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 210 - 215 (6page)
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It is already known that high concentration of vitamin C induces apoptosis on tumor cells. However, there is no report regarding the function of vitamin C on the modulation of immune susceptibility of cancer. Therefore, we investigated whether vitamin C can modulate immune susceptibility of tumor cells, especially on the induction of Fas-mediated apoptosis. First, the optimal concentration of vitamin C, which cannot induce damages on tumor cells for 36 hrs. We found that 2 mM of vitamin C did not show harmful effect. In addition, the optimal concentration of agonistic anti-Fas Abs for 18 hrs was examined. As a result, 400 ng/ml of agonistic anti-Fas Abs did not induce apoptosis on tumor cells. Next, we tried to find the effect of 2 mM of vitamin C on the modulation of the susceptibility to agonistic anti-Fas Abs. When tumor cells were cultured with 400 ng/ml of agonistic anti-Fas Abs for 18 hrs, after pre-treatment with 2 mM of vitamin C for 24 hrs, viability of cells was decreased. Interestingly, we found that the expression of Fas (CD95) and MHC class I was increased by the treatment of vitamin C. Taken together, vitamin C increases the susceptibility of tumor cells to anti-Fas Abs and the expression of Fas (CD95) and MHC class I on tumor cells.
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참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Kang JS / 2003 / L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway / Cancer Immunol Immunother 52 : 693 ~ 698
2. [학술지(정기간행물)] - Kang JS / 2005 / Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake / Journal of Cellular Physiology 204 (1) : 192 ~ 197
3. [학술지(정기간행물)] - Kim JE / 2008 / Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity / INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 22 : 651 ~ 655
4. [학술지(정기간행물)] - Hahm E / 2007 / The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma / JOURNAL OF CELLULAR BIOCHEMISTRY 102 : 1002 ~ 1010
5. [학술지(정기간행물)] - Lee SK / 2008 / Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor IIIGF-II production / JOURNAL OF CELLULAR PHYSIOLOGY 216 : 180 ~ 188
2. [학술지(정기간행물)] - Kang JS / 2005 / Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake / Journal of Cellular Physiology 204 (1) : 192 ~ 197
3. [학술지(정기간행물)] - Kim JE / 2008 / Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity / INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 22 : 651 ~ 655
4. [학술지(정기간행물)] - Hahm E / 2007 / The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma / JOURNAL OF CELLULAR BIOCHEMISTRY 102 : 1002 ~ 1010
5. [학술지(정기간행물)] - Lee SK / 2008 / Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor IIIGF-II production / JOURNAL OF CELLULAR PHYSIOLOGY 216 : 180 ~ 188
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