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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 98 - 105 (8page)
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It has been recently noticed that type 2 diabetes (T2D), one of the most common metabolic diseases, causes a chronic low-grade inflammation and activation of the innate immune system that are closely involved in the pathogenesis of T2D. Cordyceps militaris, a traditional medicinal mushroom, produces a component compound, cordycepin (3'-deoxyadenosine). Cordycepin has been known to have many pharmacological activities including immunological stimulating, anti-cancer, and anti-infection activities. The molecular mechanisms of cordycepin in T2D are not clear. In the present study, we tested the role of cordycepin on the anti-diabetic effect and anti-inflammatory cascades in LPS-stimulated RAW 264.7 cells. Methods: We confirmed the levels of diabetes regulating genes mRNA and protein of cytokines through RT-PCR and western blot analysis and followed by FACS analysis for the surface molecules. Results: Cordycepin inhibited the production of NO and pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α in LPS-activated macrophages via suppressing protein expression of pro-inflammatory mediators. T2D regulating genes such as 11β-HSD1 and PPARγ were decreased as well as expression of co-stimulatory molecules such as ICAM-1 and B7-1/-2 were also decreased with the increment of its concentration. In accordance with suppressed pro-inflammatory cytokine production lead to inhibition of diabetic regulating genes in activated macrophages. Cordycepin suppressed NF-κB activation in LPS-activated macrophages. Conclusion: Based on these observations, cordycepin suppressed T2D regulating genes through the inactivation of NF-κB dependent inflammatory responses and suggesting that cordycepin will provide potential use as an immunomodulatory agent for treating immunological diseases.
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Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines
Immune Network
2009 .12
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Cordycepin이 생쥐의 난구세포 분산과 난자의 성숙에 미치는 영향
대한불임학회잡지
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Inhibitory Effect of Cordycepin on Human Platelet Aggregation
대한의생명과학회지
2004 .03
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Release of the Pro-inflammatory Cytokines and Facilitation of Immune Response in LPS-induced Activation of Macrophage by Crude Cordycepin Containing Adenosine(CCCA) from Cordyceps militaris
대한약학회 학술대회
2003 .01
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The Inhibitory Effects of Cordycepin (3'-deoxyadenosine) on Thapsigargin-enhanced Cytosolic Ca2+-influx and -mobilization in Human Platelets
대한의생명과학회지
2009 .12
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Cordycepin protects against β–amyloid and ibotenic acid– induced hippocampal CA1 pyramidal neuronal hyperactivity
The Korean Journal of Physiology & Pharmacology
2019 .01
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Cordycepin에 의한 피부 섬유아세포 세포노쇠화 개선효과
대한화장품학회지
2015 .01
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A Rapid Manufacturing Process of Crude Cordycepin Containing Adenosine (CCCA) from Cultured Fruiting Bodies of Cordyceps Milifads (CM) for Developing Anti-leukemic Agents.
대한약학회 학술대회
2003 .01
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Immunomodulatory Effects of Dioscoreae Rhizome Against Inflammation through Suppressed Production of Cytokines Via Inhibition of the NF-κB Pathway
Immune Network
2012 .10
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三七花의 대식세포로부터 LPS에 의해 유도되는 nitric oxide와 전염증성 사이토카인의 생성 억제효과
대한한의학회지
2009 .01
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Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
Immune Network
2011 .10
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Suppressed Production of Pro-inflammatory Cytokines by LPS-Activated Macrophages after Treatment with Toxoplasma gondii Lysate
Parasites, Hosts and Diseases
2008 .09
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Immunomodulatory Activity of Betulinic Acid by Producing Pro-Inflammatory Cytokines and Activation of Macrophages
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
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Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation
대한의생명과학회지
2004 .03
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LPS로 활성화된 복강 대식세포에서 세신 추출물의 항염증 효과
대한본초학회지(본초분과학회지)
2006 .01
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Extract mulberry leaves fermented with Cordyceps militaris exerts anti inflammatory effects in LPS stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti oxidant activity
한국실험동물학회 학술발표대회 논문집
2018 .07
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