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Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.
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참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Kyriakis JM / 2001 / Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation / Physiol Rev 81 : 807 ~ 869
2. [학술지(정기간행물)] - Ichijo H / 1997 / Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways / Science 275 : 90 ~ 94
3. [학술지(정기간행물)] - Nishitoh H / 1998 / ASK1 is essential for JNK/SAPK activation by TRAF2 / Mol Cell 2 : 389 ~ 395
4. [학술지(정기간행물)] - Tobiume K / 2001 / ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis / EMBO Rep 2 : 222 ~ 228
5. [학술지(정기간행물)] - Takeda K / 2004 / Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation / EMBO Rep 5 : 161 ~ 166
2. [학술지(정기간행물)] - Ichijo H / 1997 / Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways / Science 275 : 90 ~ 94
3. [학술지(정기간행물)] - Nishitoh H / 1998 / ASK1 is essential for JNK/SAPK activation by TRAF2 / Mol Cell 2 : 389 ~ 395
4. [학술지(정기간행물)] - Tobiume K / 2001 / ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis / EMBO Rep 2 : 222 ~ 228
5. [학술지(정기간행물)] - Takeda K / 2004 / Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation / EMBO Rep 5 : 161 ~ 166
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