지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 121 - 132 (12page)
이용수
초록· 키워드
오류제보하기
Streptococcus pneumoniae, also called pneumococcus, is a major cause of infectious disease in human. Pneumococcus resides in the nasopharynx as an upper respiratory commensal, and most of pneumococcal colonizations are asymptomatic in immunocompetent individuals. When nasopharyngeal mucosal homeostasis is disrupted, pneumococcus migrates into middle ear and lower respiratory tract and causes detrimental colonization. In this regard, the epithelial cells of middle ear and lung act as first line of defense against pneumococcus to prevent invasive pneumococcal diseases. Respiratory epithelial cells express various cell-surface and intra-cellular receptors sensing microbial pathogens and respond to sensed pathogens by triggering intra-cellular signaling pathways and inducing pathogen-specific innate immune responses. Various epithelial cell-surface and intra-cellular receptors, such as Toll-like receptors (TLRs), Nod-like receptors (NLRs), intracellular DNA sensing receptors, and scavenger receptors (SRs), participate in sensing of pneumococcus, and the activation of these receptors by pneumococcal components induces anti-pneumococcal innate immune responses including epithelial apoptosis and inflammatory cytokine/chemokine expressions. Epithelial sensing of pneumococcus is a critical step for setting an early defense against pneumococcal infection, and also is required to recruit and activate innate immune cells and trigger adaptive immunity.
목차
INTRODUCTION
CONCLUSION
REFERENCES
참고문헌 (98)
참고문헌 신청
1. [학술지(정기간행물)] - Watson DA. / 1993 / A brief history of the pneumococcus in biomedical research : a panoply of scientific discovery / Clin Infect Dis 17 : 913 ~ 924
2. [학술지(정기간행물)] - / 2007 / Pneumococcal conjugate vaccine for childhood immunization--WHO position paper / Wkly Epidemiol Rec 82 : 93 ~ 104
3. [학술지(정기간행물)] - Kalin M. / 1998 / Pneumococcal serotypes and their clinical relevance / Thorax 53 : 159 ~ 162
4. [학술지(정기간행물)] - van Dam JE. / 1990 / Immunogenicity and immunochemistry of Streptococcus pneumoniae cap-sular polysaccharides / Antonie Van Leeuwenhoek 58 : 1 ~ 47
5. [학술지(정기간행물)] - Sankilampi U. / 1997 / Epidemiology of invasive Streptococcus pneumoniae infections in adults in Finland / Epidemiol Infect 118 : 7 ~ 15
2. [학술지(정기간행물)] - / 2007 / Pneumococcal conjugate vaccine for childhood immunization--WHO position paper / Wkly Epidemiol Rec 82 : 93 ~ 104
3. [학술지(정기간행물)] - Kalin M. / 1998 / Pneumococcal serotypes and their clinical relevance / Thorax 53 : 159 ~ 162
4. [학술지(정기간행물)] - van Dam JE. / 1990 / Immunogenicity and immunochemistry of Streptococcus pneumoniae cap-sular polysaccharides / Antonie Van Leeuwenhoek 58 : 1 ~ 47
5. [학술지(정기간행물)] - Sankilampi U. / 1997 / Epidemiology of invasive Streptococcus pneumoniae infections in adults in Finland / Epidemiol Infect 118 : 7 ~ 15
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