지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 37 - 43 (7page)
이용수
초록· 키워드
오류제보하기
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are among the most common causes of chronic liver disease worldwide. The host immune pressure against hepatitis viruses during the chronic infection has led to mutations in their coding genes, which could play a pivotal role in the clinical outcomes of chronic patients. Our recent molecular epidemiologic studies regarding the HBV precore/core (preC/C) regions and HCV nonstructural 5B (NS5B) protein suggest the presence of distinct CD4 T cell immune pressure against HBV and HCV in Korean chronic patients. However, induced HBV and HCV mutations seem to exert an opposite effect on Korean chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients, respectively. On the basis of two of our recent papers, we focused in this review on the relationships between the mutation patterns of HBV preC/C and HCV NS5B, which were presumed to be caused by distinct CD4 T cell pressure in the Korean population and their effect on the clinical outcomes and liver disease progression of CHB and CHC patients.
목차
Introduction
The HBV preC/C mutations from Korean patients infected with genotype C
The HCV NS5B mutation from Korean chronic patients with genotype 1b
Conclusion
REFERENCES
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Lee WM. / 1997 / Hepatitis B virus infection / N Engl J Med 337 : 1733 ~ 1745
2. [보고서] - KCDC / 2010 / Report of National Health and Nutrition Survay
3. [학술지(정기간행물)] - Shin HR. / 2006 / Epidemiology of Hepatitis C Virus in Korea / Intervirology 49 : 18 ~ 22
4. [학술지(정기간행물)] - Kidd-Ljunggren K. / 2002 / Genetic variability in hepatitis B viruses / J Gen Virol 83 : 1267 ~ 1280
5. [학술지(정기간행물)] - Miyakawa Y. / 2003 / Classifying hepatitis B virus genotypes / Intervirol 46 : 329 ~ 338
2. [보고서] - KCDC / 2010 / Report of National Health and Nutrition Survay
3. [학술지(정기간행물)] - Shin HR. / 2006 / Epidemiology of Hepatitis C Virus in Korea / Intervirology 49 : 18 ~ 22
4. [학술지(정기간행물)] - Kidd-Ljunggren K. / 2002 / Genetic variability in hepatitis B viruses / J Gen Virol 83 : 1267 ~ 1280
5. [학술지(정기간행물)] - Miyakawa Y. / 2003 / Classifying hepatitis B virus genotypes / Intervirol 46 : 329 ~ 338
이 논문의 저자 정보
최근 본 자료
댓글(0)
0