지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 270 - 278 (9page)
이용수
초록· 키워드
오류제보하기
Bronchial asthma can be triggered by microbial agents in the oropharynx. This study was designed to identify the differences in microbiota of oropharynx of bronchial asthmatic patients in contrast to normal controls. In order to resolve the qualitative and quantitative diversity of the 16S rRNA gene present in the oropharynx microbiota of 4 patients and 4 controls, we compared microbial communities using Sanger sequencing and 376 sequences of 16S rRNA gene were analyzed. Of the total microbial diversity detected in the oropharynx in asthmatic patients 45.6% comprised members of the Firmicutes. In contrast, Proteobacteria (44.0%) dominated the oropharyngeal microbiota in the normal control group. Members of the Bacteroidetes, Fusobacteria, Actinobacteria, TM7, Cyanobacteria and unclassified bacteria were present in both groups. In conclusion, the difference in the microbiota of the oropharynx between patients and normal individuals could trigger symptomatic attacks in bronchial asthma.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Ramsey CD / 2007 / Respiratory illnesses in early life and asthma and atopy in childhood / J Allergy Clin Immunol 119 : 150 ~ 156
2. [단행본] - Fishman AJ / 2010 / Fishman's Pulmonary Diseases and Disorders / McGrawHill
3. [학술지(정기간행물)] - Johnston SL / 2005 / Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis? / Am J Respir Crit Care Med 172 : 1078 ~ 1089
4. [학술지(정기간행물)] - Kraft M / 2002 / Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin / Chest 121 : 1782 ~ 1788
5. [학술지(정기간행물)] - Kraft M / 2008 / Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma / Eur Respir J 31 : 43 ~ 46
2. [단행본] - Fishman AJ / 2010 / Fishman's Pulmonary Diseases and Disorders / McGrawHill
3. [학술지(정기간행물)] - Johnston SL / 2005 / Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis? / Am J Respir Crit Care Med 172 : 1078 ~ 1089
4. [학술지(정기간행물)] - Kraft M / 2002 / Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin / Chest 121 : 1782 ~ 1788
5. [학술지(정기간행물)] - Kraft M / 2008 / Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma / Eur Respir J 31 : 43 ~ 46
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