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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 92 - 98 (7page)
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초록· 키워드
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Nucleoside diphosphate kinase (Ndk) is ubiquitous and highly conserved multifunctional key enzyme in nucleotide metabolism. It generates nucleoside triphosphates (NTPs) by transfer of gamma-phosphates from nucleoside triphosphates such as ATP or GTP to nucleoside diphosphate. The formation of an autophosphorylated enzyme intermediate is involved in that mechanism. The phosphate is usually supplied by ATP and Ndk activity in different subcellular compartments. Ndk may regulate the crucial balance between ATP and GTP or other nucleoside triphosphates. Ndk is playing an important role in bacterial pathogenesis and emerging evidences recognize multiple roles of Ndk in host-microbe interaction. Here, I review some examples of the role of Ndk in intra- and extracellular microorganism.
목차
1. 서론
2. 푸린수용체(purinergic receptor)를 통한 병원성 세균유래 Ndk의 기능
3. Intracellular bacteria에서의 Ndk의 기능
4. Extracellular bacteria에서의 Ndk의 기능
5. 숙주세포 내에서 외부로의 Ndk의 분비기전
6. 세균에서의 Ndk의 분비기전
7. 결론
참고문헌
참고문헌 (43)
참고문헌 신청
1. [단행본] - Clark VL / 1994 / Bacterial pathogenesis, part A: identification and regulation of virulence factors, In Methods in Enzymology vol. 235 / Academic Press
2. [학술지(정기간행물)] - Chakrabarty AM. / 1998 / Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis / Mol Microbiol 28 : 875 ~ 882
3. [학술지(정기간행물)] - Dar HH / 2011 / Secretory nucleoside diphosphate kinases from both intra- and extracellular pathogenic bacteria are functionally indistinguishable / Microbiology 157 : 3024 ~ 3035
4. [학술지(정기간행물)] - Punj V / 2000 / Phagocytic cell killing mediated by secreted cytotoxic factors of Vibrio cholerae / Infect Immun 68 : 4930 ~ 4937
5. [학술지(정기간행물)] - Melnikov A / 2000 / Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells / Mol Microbiol 36 : 1481 ~ 1493
2. [학술지(정기간행물)] - Chakrabarty AM. / 1998 / Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis / Mol Microbiol 28 : 875 ~ 882
3. [학술지(정기간행물)] - Dar HH / 2011 / Secretory nucleoside diphosphate kinases from both intra- and extracellular pathogenic bacteria are functionally indistinguishable / Microbiology 157 : 3024 ~ 3035
4. [학술지(정기간행물)] - Punj V / 2000 / Phagocytic cell killing mediated by secreted cytotoxic factors of Vibrio cholerae / Infect Immun 68 : 4930 ~ 4937
5. [학술지(정기간행물)] - Melnikov A / 2000 / Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells / Mol Microbiol 36 : 1481 ~ 1493
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