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논문 기본 정보

자료유형
학술저널
저자정보
Chan-Ki Min (Seoul National University) Myung-Sik Choi (Seoul National University) Ik-Sang Kim (Seoul National University) Nam-Hyuk Cho (Seoul National University)
저널정보
대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY Journal of Bacteriology and Virology 제44권 제4호
발행연도
2014.12
수록면
352 - 358 (7page)

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초록· 키워드

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Type 1 Interferons (T1 IFN) play a pivotal role in innate immune responses against viral infection. Recently, this anti-viral cytokines are shown to be induced during bacterial infections via activation of various pattern recognition receptors (PRRs) including Toll-like receptors, RIG-I-like receptors, or NOD-like receptors. Signaling mediators such as MyD88, TRIF, MAVS, STING, or RIP2 of the receptor signaling pathways are also involved in T1 IFN responses depending on the bacterial species and their ligands. However, role of T1 IFN in anti-bacterial immunity is still obscure and its effect on immunological pathogenesis during bacterial infection has been controversial. It has been reported that T1 IFN could provide protective effect on several bacterial infections but it also aggravates pathogenic situation during some intracellular pathogens or secondary bacterial infection after respiratory viral infection. Here, we summarize recent findings how T1 IFN is induced by various bacterial pathogens and discuss the potential effect of T1 IFN responses on immune responses against bacterial infection.

목차

세균감염에 의해 1형 인터페론 발현을 조절하는 신호전달체계
세균감염에서 1형 인터페론의 영향
CONCLUSION
REFERENCES

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