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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.12
- 수록면
- 271 - 282 (12page)
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초록· 키워드
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The nested polymerase chain reaction (PCR) assay was used to determine the sequences of reverse transcriptase (RT) codons 41, 67, 70, 210, 215 and 219 of human immunodeficiency virus-1 (HIV-1) pol gene. Template DNA was obtained from uncultured peripheral blood mononuclear cells from 27 Korean HIV-1 infected patients treated with ZDV and Korean red ginseng. The second PCRs were done for 2 separated regions (RT codons 13-98 and 152 259) with 5 ㎕ of the first PCR product. Nucleotide sequences were determined by direct sequencing. In the 27 patients, CD4+ cell count decreased from 230±117/㎕ to 152±162/㎕ for 46±26 months (Mo), and actual duration of ZDV intake was 27±16 Mo. In the 16 patients who had been treated with ZDV therapy ≥25 Mo, the incidences of 70R, 215F/Y, and 41L were 61%, 28% and 22%, respectively and those of 67N, 210W and 219Q were 17%. The incidences of 215F/Y were 6.7% for group ≤12 Mo treatment, 22.7% for group with 13 to 24 Mo, and 27.8% for group ≥25 Mo. There was no mutation in 9 patients. It might be associated with the interruption of ZDV therapy for more than 6 months in 6 patients. This study shows that the detection of mutation could be useful prognostic marker with other clinical and virological data, and very low mutation rate is dectected compared to overseas reports.
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