지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1998.3
- 수록면
- 63 - 69 (7page)
이용수
초록· 키워드
오류제보하기
To establish in vivo antiviral evaluation system by using murine herpesvirus intracerebral infection model, 5-6 female BALB/c mice per group aged 5 weeks were inoculated I.c. into cerebrum with different inocular HSV-1 F. Signs of clinical disease noted everyday for one month. Observed were body weight decrease, neurological signs and death caused by encephalitis. Mice discontinued body weight decrease were recovered from the disease, and keratitis was often observed during recovery. The groups inoculated with higher than 1,000 PFU showed 100% mortaltiy and LDp was <100 PFU/mouse. To study the effect of virus inoculum sizes on antiviral effect of acyclovir (ACV), mice inoculated with different inocula were administered I.p. with different doses of ACV immediately after infection, and twice a day for 5 days. The higher inculum size, the less protective. Edp of ACV was >25, >25, 18.4 and 8.0 mg/kg b.I.d. in the group infected with 1,000,000, 100,000, 10,000 and 1,000 PFU/mouse, respectively. LD of ACV was 62.5 mg/kg b.I.d. Therapeutic index of ACV was <2.5, <2.5, 3.0 and 7.0 in the groups with inocula 1,000,000, 100,000, 10,000 and 1,000 PFU/mouse, respectively. Inoculum size 1,000 PFU/mouse showing 100% mortaltiy and 5-6 days mean time to death, 5 days drug administration and 14 days observation will be future exeperimental conditions.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Herpes Simplex Virus Type 1 마우스 뇌염모델에서의 조직내 바이러스 증식 및 재활성에 미치는 Acyclovir의 약효
JOURNAL OF BACTERIOLOGY AND VIROLOGY
1999 .09
-
가족 내 수두 환자와 접촉 후 경구 Acyclovir의 예방효과
Pediatric Infection and Vaccine
2002 .01
-
Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
Overexpression of hARD1235 accelerates Tumorigenesis in APCMIN/+Mice
한국실험동물학회 학술발표대회 논문집
2009 .04
-
Inflammatory Large Bowel Disease due to Helicobacter hepaticus infection in BALB/cA-Hfh11nu Mice
Laboratory Animal Research
2002 .09
-
지속적인 경구용 Acyclovir 억제요법이 요구된 미숙아의 재발성 단순포진 바이러스 감염 1례
Clinical and Experimental Pediatrics
2003 .01
-
Metabolism of acyclovir, ganciclovir and penciclovir in infected cells with acyclovir-resistant and wild-type strains of herpes simplex virus type 1
대한약학회 학술대회
2000 .01
-
파종성 신생아 단순포진 바이러스 감염
Acute and Critical Care
2013 .01
-
From breeding mouse to editing mouse genome
한국실험동물학회 학술발표대회 논문집
2017 .08
-
단순 포진 바이러스 감염 생쥐에 대한 아데닌 아라비노사이드와 그의 프레드니손 결합화합물인 BR-8702-AP의 항바이러스 효과
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1993 .01
-
객관적 전정기능의 장애가 동반된 감각신경성 난청 환자의 특성
대한이비인후-두경부외과학회지
2019 .01
-
Neonatal Meningoencephalitis caused by Herpes Simplex Virus Type 2
Pediatric Infection and Vaccine
2014 .01
-
성기단순포진의 권고치료
Urogenital Tract Infection
2014 .01
-
Modeling human disease in mouse models
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Acyclovir 치료 중에 뇌혈종이 합병된 헤르페스 수막뇌염
대한뇌졸중학회지
2011 .01
-
Curcumin Inhibits Phorbol Ester-induced Expression of Cyclooxygenase-2 In Vivo through Suppression of Extracelluar Signal-regulated Kinase (ERK) 1/2 and NF-${\kappa}$/B in Mouse Skin
대한약학회 학술대회
2002 .01
-
Mice vs. Men
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Studies on the Small Body Size Mouse Developed by Mutagen N-Ethyl-N-nitrosourea
Toxicological Research
2008 .03
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0