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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제26권 제2호
발행연도
1996.12
수록면
273 - 283 (11page)

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초록· 키워드

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In order to search for anti-influenza virus type A agents from Korean traditional prescriptions (herb complexes), we selected 63 traditional prescriptions, based on a review of the Korean traditional medicine books. Both methanol extracts and boiling-water extracts were tested, by means of the Haemagglutination Inhibition Test (HIT). Three of the 63 methanol extracts: CM-22, CM-26, CM-48 (see explanation of nomenclature below), showed efficacy against influenza virus type A. CM-22 showed anti-influenza virus type A activity at the range of 313pg/ml to 9.75pg/ml, CM-26 showed antiviral activity at the range of 156pl/ml to 4.87pg/ml, CM-48 showed anti-influenza virus type A activity at the range of 625pg/ml to 19.5pg/ml, respectively. Three of the water extracts: CW-14, CW-34, CW-61 were active. CW-14 showed anti-influenza virus type A activity at the range of 10mg/ml to 78pg/ml, CW-34 showed antiviral activity at the range of 10mg/ml to 625pg/ml and CW-61 showed anti- influenza virus type A activity at the range of 10mg/ml to 313pg/ml, respectively. In order to determine cytotoxicity of each extracts, chicken red blood cells were incubated with the various concentration of extracts of Korean traditional prescriptions. CW-14, CW-34 and CW-61 did not show cytotoxic effect against red blood cells whereas CM-22, CM-26 and CM-48 showed cytotoxic effect against red blood cells at the range of 10mg/ml to 625pg/ml, 10mg/ml to 313pg/ml and 10mg/ml to 313pg/ml, respectively. These results indicated that Korean traditional prescriptions may be inhibit either attachment of virus to cell surface receptor or penetration of the virus into cell during the initial stage of infection.

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