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학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제24권 제2호
발행연도
1994.12
수록면
199 - 206 (8page)

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Scrapie is a degenerative disease of central nervous system of sheep and a few other animals. Amyloid plaque and vacuolation which of the signs of senile dementia are found in the brain of scrapie-infected animals. The significant decrease of aminergic neurotransmitter may be a major cause of clinical symptom such as ataxia and head bubbing. So we tried to measure the concentration of neurotransmitter with HPLC. The overall decrease of the concentration of adrenergic and serotonergic neurotransmitter was measured. The significant decrease of norepinephrine in cerebral cortex of 87-infected IM mouse brain and dopamine in brain stem of 263K- infected hamster was shown. The involvement of oxygen free radical in various degenerative disease was thought to play important role in processing of neurodegenerative disease, however, 8-0HdG, the indicator of DNA oxidation by free radicals, was not altered in number in the brain of scrapie-infected animals, And the activities of antioxidant enzymes located in cytosol were not altered either, except that of glutathione reductase of hamster brain. Glutathione reductase is concerned with lipid peroxidation. So these results provide the possibility of relationship between neuropathological changes and rnembrane lipid peroxidation in scrapie agent- infected animals.

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