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학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제24권 제1호
발행연도
1994.6
수록면
77 - 86 (10page)

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Aseptic meningitis is known that the sign of neurological diseases are present except paralysis even though the main sign and symptoms are fever and headache with nuchal rigidity of which is stiffness of the neck muscles due to meningeal irritation but the damage is minor. Outbreakes are very common in young aged group during the warm season through the infection is spread mainly by the fecal-oral route from virus excretors to contacts and virus in pharyngeal secretion is also source of infection. Since sporadic clinical cases of aseptic meningitis has reported in 1990, one of epidemic during the month of May, 1993 due to let enterovirus teams in NIH, Korea carried out seroepidemiological investigation against cases of aseptic meningitis which is a first time in Korea. Stool and CSF specimens from 3S patients with aseptic meningitis were tested by neutralization test and PCR derived from the highly conserved 5-noncoding enterovirus' genomic region. We found a higher infection rate in the 1-9 years old group(68.5 %) and in the male sex(68.5 / ). ECHO type 9 and 30 were isolated in fecal specimens and coxsackie type B was isolated in CSF. The PCR assay yielded positive results in 7 cases where enterovirus diagnosis were obtained by serological test.

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