지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Oct4 is a member of the OCT protein family.The Oct-4gene encodes a transcription factor that isspecifically expressed in embryonic stem cells and germ cells ofthe mouse embryo. The key role of Oct4 in the pluripotency regulator network is well documented. The Oct4 has been shown as a master regulator in maintaining the pluripotecy and self?renewal in embryonic stem cells (ESCs), but it’s not essential for the initiation of totipotecy and pluripotecy. This conclusion is further supported by the formation ofOct4 -GFP ? and Nanog- expressing inner cellmasses (ICMs) in embryos with complete inactivation of both maternal and zygotic Oct4 express ion and thereprogramming of fibroblasts into fully pluripotent cells by Oct4 -deficient oocytes. In addition, Oct4 is also an important component in generating iPS cells. In contrast to its critical role in pluripotency, maternal Oct4 expression is not critical for developmental competence of the oocyte. In this review, we summarize the function of Oct4 in mammalian embryonic development.
목차
ABSTRACT
Introduction
The structure of Oct4
The isoforms of Oct4
Oct4 and pluripotecy
Oct4 and the oocyte developmental competence
Conclusion
Reference
참고문헌 (1)
참고문헌 신청
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Oct4-Transfection한 중간엽줄기세포 유래 핵이식 배반포의 Oct4 발현 분포 및 세포 자멸사의 변화에 관한 연구
한국수정란이식학회지
2016 .01
-
배아추출물 공여 배아의 발생단계가 바다송사리(Oryzias dancena) 배아 줄기세포 유사세포의 배양에 미치는 영향
한국수산과학회지
2017 .04
-
Stem Cell-Derived Conditioned Medium 첨가가 돼지난자의 체외성숙 및 단위발생란의 초기배 발육에 미치는 영향
한국동물번식학회지
2015 .01
-
Follistatins have potential functional role in Porcine Embryogenesis
Korean Journal of Agricultural Science
2016 .03
-
Lysophosphatidic acid improves development of porcine somatic cell nuclear transfer embryos
한국축산학회지
2024 .07
-
Pluripotency Related Gene Expression Profiling in Chicken Early Embryo
한국가금학회 정기총회 및 학술발표회
2015 .11
-
Establishment of conditions for long-term maintenance of primary embryonic cell cultures from olive flounder Paralichthys olivaceus
한국수산과학회 양식분과 학술대회
2021 .04
-
Effect of Monosodium Glutamate on In Vitro Oocyte Maturation and Embryonic Development after Parthenogenesis in Pigs
한국수정란이식학회지
2017 .01
-
곰소만의 해수 및 패류에 있어서 장염비브리오균(Vibrio parahaemolyticus) 과 비브리오패혈증균(Vibrio vulnificus)의 분포
한국수산과학회지
2019 .04
-
Effects of incubation temperature on the embryonic viability and hatching time in Russian sturgeon (Acipenser gueldenstaedtii)
Fisheries and Aquatic Sciences
2018 .01
-
Effects of (-)-Epicatechin Gallate on porcine oocyte in vitro maturation and subsequent embryonic development after parthenogenetic activation and in vitro fertilization
한국수정란이식학회지
2016 .01
-
Effect of Alpha Lipoic Acid as an Antioxidant Supplement during In Vitro Maturation Medium on Bovine Embryonic Development
한국수정란이식학회지
2017 .01
-
Exogenous Nitric Oxide Donation During In Vitro Maturation Improves Embryonic Development after Parthenogenesis and Somatic Cell Nuclear Transfer in Pigs
한국수정란이식학회지
2018 .01
-
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
한국식품영양과학회 학술대회발표집
2016 .10
-
Effect of Alpha Lipoic Acid on in vitro Maturation of Porcine Oocytes and Subsequent Embryonic Development after Parthenogenetic Activation
한국수정란이식학회지
2017 .01
-
Rapamycin treatment during prolonged in vitro maturation enhances the developmental competence of immature porcine oocytes
한국축산학회지
2024 .09
-
The influence and role of melatonin on in vitro oocyte maturation and embryonic development in pig and cattle
Korean Journal of Agricultural Science
2017 .09
-
Investigation of gene expression in primary embryonic cell line (FGBC8) from olive flounder Paralichthys olivaceus
Fisheries and Aquatic Sciences
2021 .11
-
Adverse effect of IL-6 on the in vitro maturation of porcine oocytes
Korean Journal of Agricultural Science
2021 .09
-
Endoplasmic Stress Inhibition during Oocyte Maturation Improves Preimplantation Development of Cloned Pig Embryos
한국수정란이식학회지
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-527-001613917