지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.5
- 발행연도
- 2015.4
- 수록면
- 276 - 280 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model.
Methods: Orthotopic kidney transplantation was performed in a BALB/c -to- C57BL/6j or C57BL/6j-to- C57BL/6j mouse model. After optimizing imaging techniques, five mice were imaged with micro-CT and the findings were verified histologically.
Results: Micro-CT can monitor and evaluate renal location and function after orthotopic kidney transplantation. There were no mice deaths while renal transplants were failure.
Conclusion: We propose that graft micro-CT imaging is a new option that is noninvasive and specific, and can aid in early detection and follow-up of acute renal rejection. This method is potentially useful to improve posttransplant rejection monitoring.
Methods: Orthotopic kidney transplantation was performed in a BALB/c -to- C57BL/6j or C57BL/6j-to- C57BL/6j mouse model. After optimizing imaging techniques, five mice were imaged with micro-CT and the findings were verified histologically.
Results: Micro-CT can monitor and evaluate renal location and function after orthotopic kidney transplantation. There were no mice deaths while renal transplants were failure.
Conclusion: We propose that graft micro-CT imaging is a new option that is noninvasive and specific, and can aid in early detection and follow-up of acute renal rejection. This method is potentially useful to improve posttransplant rejection monitoring.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (14)
참고문헌 신청
1. [학술지(정기간행물)] - Ge F. / 2011 / Strategies for successfully establishing a kidney transplant in a mouse model / Exp Clin Transplant 9 : 287 ~ 294
2. [학술지(정기간행물)] - Tse GH. / 2013 / Systematic review of mouse kidney transplantation / Transpl Int 26 : 1149 ~ 1160
3. [학술지(정기간행물)] - Schambach SJ. / 2010 / Application of micro-CT in small animal imaging / Methods 50 : 2 ~ 13
4. [학술지(정기간행물)] - Azuma H. / 2010 / Induction of donorspecific tolerance using superagonistic CD28 antibody in rat renal allografts : regulatory T-cell expansion before engraftment may be important / Transplantation 90 : 1328 ~ 1335
5. [학술지(정기간행물)] - Abe T. / 2012 / Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury / Transplantation 94 : 14 ~ 21
2. [학술지(정기간행물)] - Tse GH. / 2013 / Systematic review of mouse kidney transplantation / Transpl Int 26 : 1149 ~ 1160
3. [학술지(정기간행물)] - Schambach SJ. / 2010 / Application of micro-CT in small animal imaging / Methods 50 : 2 ~ 13
4. [학술지(정기간행물)] - Azuma H. / 2010 / Induction of donorspecific tolerance using superagonistic CD28 antibody in rat renal allografts : regulatory T-cell expansion before engraftment may be important / Transplantation 90 : 1328 ~ 1335
5. [학술지(정기간행물)] - Abe T. / 2012 / Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury / Transplantation 94 : 14 ~ 21
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UCI(KEPA) : I410-ECN-0101-2016-514-001396214