지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 174 - 179 (6page)
- DOI
- 10.15188/kjopp.2015.04.29.2.174
이용수
초록· 키워드
오류제보하기
Transcription factor, Nrf2 was well known to protect cell from oxidative stress by up-regulating it’s dependent anti-oxidative genes such as HO-1 and NQO1. Cheongjogupye-tang (CJGPT), a traditional herbal formula was originally recorded in 『EuiMunBeopRyul』, still having been used to treat pulmonary disease such as asthma and pulmonary inflammation, in Eastern Asian countries. However, the underlying therapeutic mechanisms remain elusive. The purpose of this study is to investigate the anti-inflammatory or anti-oxidative effects of CJGPT on the RAW 264.7 cells. To examine the anti-inflammatory or anti-oxidative effects of CJGPT, MTT assay, immunoblotting, RT-PCR and reporter gene assays were performed. Although CJGPT slightly suppressed the nuclear NF-κB expression, it did not decreased the expression of pro-inflammatory genes in LPS-stimulated RAW 264.7 cells. Moreover, it did not increased the transcriptional activity of NF-κB in reporter gene assay. However, CJGPT upregulated the nuclear expression of Nrf2, as well as increased the expression of Nrf2-dependent genes such as HO-1 and NQO1. In addition, CJGPT incresed the transcriptional activity of Nrf2. Taken together, our results showed that CJGPT exerts functions as an anti-oxidant mainly by activating Nrf2.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Balaban, R. S. / 2005 / Mitochondria, oxidants, and aging / Cell 120 (4) : 483 ~ 495
2. [학술지(정기간행물)] - Ray, P. D. / 2012 / Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling / Cell Signal 24 (5) : 981 ~ 990
3. [학술지(정기간행물)] - Shukla, V. / 2011 / Oxidative stress in neurodegeneration / Adv Pharmacol Sci 2011 : 572634 ~
4. [학술지(정기간행물)] - Trachootham, D. / 2009 / Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? / Nat Rev Drug Discov 8 (7) : 579 ~ 591
5. [학술지(정기간행물)] - Andersen, J.K. / 2004 / Oxidative stress in neurodegeneration: cause or consequence? / Nat Med 10 : S18 ~ S25
2. [학술지(정기간행물)] - Ray, P. D. / 2012 / Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling / Cell Signal 24 (5) : 981 ~ 990
3. [학술지(정기간행물)] - Shukla, V. / 2011 / Oxidative stress in neurodegeneration / Adv Pharmacol Sci 2011 : 572634 ~
4. [학술지(정기간행물)] - Trachootham, D. / 2009 / Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? / Nat Rev Drug Discov 8 (7) : 579 ~ 591
5. [학술지(정기간행물)] - Andersen, J.K. / 2004 / Oxidative stress in neurodegeneration: cause or consequence? / Nat Med 10 : S18 ~ S25
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UCI(KEPA) : I410-ECN-0101-2016-519-001383038