지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.4
- 발행연도
- 2015.3
- 수록면
- 208 - 214 (7page)
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초록· 키워드
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Purpose: Acute portal and splenic vein thrombosis (APSVT) after hepatobiliary and pancreatic (HBP) surgery is a rare but serious complication and a treatment strategy has not been well established. To assess the safety and efficacy of anticoagulation therapy for treating APSVT after HBP surgery.
Methods: We performed a retrospective case-control study of 82 patients who were diagnosed with APSVT within 4 weeks after HBP surgery from October 2002 to November 2012 at a single institute. We assigned patients to the anticoagulation group (n = 32) or nonanticoagulation group (n = 50) and compared patient characteristics, complications, and the recanalization rate of APSVT between these two groups.
Results: APSVT was diagnosed a mean of 8.6 ± 4.8 days after HBP surgery. Patients’ characteristics were not significantly different between the two groups. There were no bleeding complications related to anticoagulation therapy. The 1-year cumulative recanalization rate of anticoagulation group and nonanticoagulation group were 71.4% and 34.1%, respectively, which is statistically significant (log-rank test, P = 0.0001). In Cox regression model for multivariate analysis, independent factors associated with the recanalization rate of APSVT after HBP surgery were anticoagulation therapy (P = 0.003; hazard ration [HR], 2.364; 95% confidence interval [CI], 1.341?4.168), the absence of a vein reconstruction procedure (P = 0.027; HR, 2.557; 95% CI, 1.111?5.885), and operation type (liver resection rather than pancreatic resection; P = 0.005, HR, 2.350; 95% CI, 1.286?4.296).
Conclusion: Anticoagulation therapy appears to be a safe and effective treatment for patients with APSVT after HBP surgery. Further prospective studies of larger patient populations are necessary to confirm our findings.
Methods: We performed a retrospective case-control study of 82 patients who were diagnosed with APSVT within 4 weeks after HBP surgery from October 2002 to November 2012 at a single institute. We assigned patients to the anticoagulation group (n = 32) or nonanticoagulation group (n = 50) and compared patient characteristics, complications, and the recanalization rate of APSVT between these two groups.
Results: APSVT was diagnosed a mean of 8.6 ± 4.8 days after HBP surgery. Patients’ characteristics were not significantly different between the two groups. There were no bleeding complications related to anticoagulation therapy. The 1-year cumulative recanalization rate of anticoagulation group and nonanticoagulation group were 71.4% and 34.1%, respectively, which is statistically significant (log-rank test, P = 0.0001). In Cox regression model for multivariate analysis, independent factors associated with the recanalization rate of APSVT after HBP surgery were anticoagulation therapy (P = 0.003; hazard ration [HR], 2.364; 95% confidence interval [CI], 1.341?4.168), the absence of a vein reconstruction procedure (P = 0.027; HR, 2.557; 95% CI, 1.111?5.885), and operation type (liver resection rather than pancreatic resection; P = 0.005, HR, 2.350; 95% CI, 1.286?4.296).
Conclusion: Anticoagulation therapy appears to be a safe and effective treatment for patients with APSVT after HBP surgery. Further prospective studies of larger patient populations are necessary to confirm our findings.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Janssen HL. / 2001 / Extrahepatic portal vein thrombosis : aetiology and determinants of survival / Gut 49 : 720 ~ 724
2. [학술지(정기간행물)] - Smoot RL. / 2006 / Durability of portal venous reconstruction following resection during pancreaticoduodenectomy / J Gastrointest Surg 10 : 1371 ~ 1375
3. [학술지(정기간행물)] - Thomas RM. / 2010 / Management of acute post-operative portal venous thrombosis / J Gastrointest Surg 14 : 570 ~ 577
4. [학술지(정기간행물)] - Kumar S. / 2001 / Mesenteric venous thrombosis / N Engl J Med 345 : 1683 ~ 1688
5. [학술지(정기간행물)] - Plessier A. / 2010 / Acute portal vein thrombosis unrelated to cirrhosis : a prospective multicenter follow-up study / Hepatology 51 : 210 ~ 218
2. [학술지(정기간행물)] - Smoot RL. / 2006 / Durability of portal venous reconstruction following resection during pancreaticoduodenectomy / J Gastrointest Surg 10 : 1371 ~ 1375
3. [학술지(정기간행물)] - Thomas RM. / 2010 / Management of acute post-operative portal venous thrombosis / J Gastrointest Surg 14 : 570 ~ 577
4. [학술지(정기간행물)] - Kumar S. / 2001 / Mesenteric venous thrombosis / N Engl J Med 345 : 1683 ~ 1688
5. [학술지(정기간행물)] - Plessier A. / 2010 / Acute portal vein thrombosis unrelated to cirrhosis : a prospective multicenter follow-up study / Hepatology 51 : 210 ~ 218
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UCI(KEPA) : I410-ECN-0101-2016-514-001306712