지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 605 - 612 (8page)
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초록· 키워드
오류제보하기
Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Lehmann T / 2006 / Globalization and the population structure of Toxoplasma gondii / Proc Natl Acad Sci USA 103:11423~11428
임혜미 / 2012 / Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea / The Korean Journal of Parasitology 50(4):287~293
표경호 / 2010 / Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice / The Korean Journal of Parasitology 48(2):171~174
Jung BK / 2012 / Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer's disease / PLoS One 7:e33312
Miyahara K / 1992 / Antitumor activity of Toxoplasma lysate antigen against methylcholanthrene-induced tumor-bearing rats / J Vet Med Sci 54:221~228
임혜미 / 2012 / Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea / The Korean Journal of Parasitology 50(4):287~293
표경호 / 2010 / Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice / The Korean Journal of Parasitology 48(2):171~174
Jung BK / 2012 / Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer's disease / PLoS One 7:e33312
Miyahara K / 1992 / Antitumor activity of Toxoplasma lysate antigen against methylcholanthrene-induced tumor-bearing rats / J Vet Med Sci 54:221~228
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UCI(KEPA) : I410-ECN-0101-2016-513-001291977